Author, as appears in the article.: Nguyen, NP; Thariat, J; Gorobets, O; Vinh-Hung, V; Kim, L; Blanco, SC; Vasileiou, M; Arenas, M; Mazibuko, T; Giap, H; Vincent, F; Chi, A; Loganadane, G; Mohammadianpanah, M; Rembielak, A; Karlsson, U; Ali, A; Bose, S; Page, BR
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arenas Prat, Meritxell
Keywords: Radiation-therapy Older Locally advanced Hypofractionated radiotherapy Cutaneous squamous cell Cpis tumor survival skin-cancer pembrolizumab pd-l1 expression locally advanced hypofractionated radiotherapy gender disparities cutaneous squamous cell cpis clinical-trials basal-cell
Abstract: Cutaneous skin carcinoma is a disease of older patients. The prevalence of cutaneous squamous-cell carcinoma (cSCC) increases with age. The head and neck region is a frequent place of occurrence due to exposure to ultraviolet light. Surgical resection with adjuvant radiotherapy is frequently advocated for locally advanced disease to decrease the risk of loco-regional recurrence. However, older cancer patients may not be candidates for surgery due to frailty and/or increased risk of complications. Radiotherapy is usually advocated for unresectable patients. Compared to basal-cell carcinoma, locally advanced cSCC tends to recur locally and/or can metastasize, especially in patients with high-risk features such as poorly differentiated histology and perineural invasion. Thus, a new algorithm needs to be developed for older patients with locally advanced head and neck cutaneous squamous-cell carcinoma to improve their survival and conserve their quality of life. Recently, immunotherapy with checkpoint inhibitors (CPIs) has attracted much attention due to the high prevalence of program death ligand 1 (PD-L1) in cSCC. A high response rate was observed following CPI administration with acceptable toxicity. Those with residual disease may be treated with hypofractionated radiotherapy to minimize the risk of recurrence, as radiotherapy may enhance the effect of immunotherapy. We propose a protocol combining CPIs and hypofractionated radiotherapy for older patients with locally advanced cutaneous head and neck cancer who are not candidates for surgery. Prospective studies should be performed to verify this hypothesis.
Thematic Areas: Oncology Medicina iii Cancer research
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: meritxell.arenas@urv.cat
Author identifier: 0000-0003-0815-2570
Record's date: 2023-12-02
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6694/15/20/4981
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cancers. 15 (20):
APA: Nguyen, NP; Thariat, J; Gorobets, O; Vinh-Hung, V; Kim, L; Blanco, SC; Vasileiou, M; Arenas, M; Mazibuko, T; Giap, H; Vincent, F; Chi, A; Loganadane, (2023). Immunotherapy and Hypofractionated Radiotherapy in Older Patients with Locally Advanced Cutaneous Squamous-Cell Carcinoma of the Head and Neck: A Proposed Paradigm by the International Geriatric Radiotherapy Group. Cancers, 15(20), -. DOI: 10.3390/cancers15204981
Article's DOI: 10.3390/cancers15204981
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV