Synthetically defined glycoprotein vaccines: current status and future directions

Identifier:  imarina:9331860

Handle: https://hdl.handle.net/20.500.11797/imarina9331860

Authors:  Adamo, Roberto; Nilo, Alberto; Castagner, Bastien; Boutureira, Omar; Berti, Francesco; Bernardes, Gonalo J L

Abstract:
Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.