Articles producció científica> Química Analítica i Química Orgànica

Synthetically defined glycoprotein vaccines: current status and future directions

  • Identification data

    Identifier: imarina:9331860
    Handle: https://hdl.handle.net/20.500.11797/imarina9331860
    Authors:
    Adamo, RobertoNilo, AlbertoCastagner, BastienBoutureira, OmarBerti, FrancescoBernardes, Gonalo J. L.
    Abstract:
    Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.

  • Others:

    Author, as appears in the article.: Adamo, Roberto; Nilo, Alberto; Castagner, Bastien; Boutureira, Omar; Berti, Francesco; Bernardes, Gonalo J. L.;
    Department: Química Analítica i Química Orgànica
    URV's Author/s: Boutureira Martín, Omar
    Keywords: Solid-phase synthesis Oligosaccharide synthesis Immunological evaluation Immune-responses Glycopeptide Conjugate vaccine Clostridium-difficile Chemoenzymatic synthesis Breast-cancer patients Antibodies
    Abstract: Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.
    Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Ciências biológicas iii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: omar.boutureira@urv.cat
    Author identifier: 0000-0002-0768-8309
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc50862e
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Chemical Science. 4 (8): 2995-3008
    APA: Adamo, Roberto; Nilo, Alberto; Castagner, Bastien; Boutureira, Omar; Berti, Francesco; Bernardes, Gonalo J. L.; (2013). Synthetically defined glycoprotein vaccines: current status and future directions. Chemical Science, 4(8), 2995-3008. DOI: 10.1039/c3sc50862e
    Article's DOI: 10.1039/c3sc50862e
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2013
    Publication Type: Journal Publications

  • Keywords:

    Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Solid-phase synthesis
    Oligosaccharide synthesis
    Immunological evaluation
    Immune-responses
    Glycopeptide
    Conjugate vaccine
    Clostridium-difficile
    Chemoenzymatic synthesis
    Breast-cancer patients
    Antibodies
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Ciências biológicas iii
    Ciências biológicas i
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Astronomia / física

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