Author, as appears in the article.: Adamo, Roberto; Nilo, Alberto; Castagner, Bastien; Boutureira, Omar; Berti, Francesco; Bernardes, Gonalo J L
Department: Química Analítica i Química Orgànica
URV's Author/s: Boutureira Martín, Omar
Keywords: Solid-phase synthesis Oligosaccharide synthesis Immunological evaluation Immune-responses Glycopeptide Conjugate vaccine Clostridium-difficile Chemoenzymatic synthesis Breast-cancer patients Antibodies
Abstract: Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.
Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Ciências biológicas iii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: omar.boutureira@urv.cat
Author identifier: 0000-0002-0768-8309
Record's date: 2024-11-30
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Chemical Science. 4 (8): 2995-3008
APA: Adamo, Roberto; Nilo, Alberto; Castagner, Bastien; Boutureira, Omar; Berti, Francesco; Bernardes, Gonalo J L (2013). Synthetically defined glycoprotein vaccines: current status and future directions. Chemical Science, 4(8), 2995-3008. DOI: 10.1039/c3sc50862e
Entity: Universitat Rovira i Virgili
Journal publication year: 2013
Publication Type: Journal Publications
Repositori URV