Articles producció científica> Medicina i Cirurgia

Metabolic adaptations in severe obesity: Insights from circulating oxylipins before and after weight loss

  • Identification data

    Identifier: imarina:9333650
  • Authors:

    Jiménez-Franco, A
    Castañé, H
    Martínez-Navidad, C
    Placed-Gallego, C
    Hernández-Aguilera, A
    Fernández-Arroyo, S
    Samarra, I
    Canela-Capdevila, M
    Arenas, M
    Zorzano, A
    Hernández-Alvarez, MI
    del Castillo, D
    Paris, M
    Menendez, JA
    Camps, J
    Joven, J
  • Others:

    Author, as appears in the article.: Jiménez-Franco, A; Castañé, H; Martínez-Navidad, C; Placed-Gallego, C; Hernández-Aguilera, A; Fernández-Arroyo, S; Samarra, I; Canela-Capdevila, M; Arenas, M; Zorzano, A; Hernández-Alvarez, MI; del Castillo, D; Paris, M; Menendez, JA; Camps, J; Joven, J
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    URV's Author/s: Arenas Prat, Meritxell / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Del Castillo Déjardin, Daniel / FERNANDEZ ARROYO, SALVADOR / Jiménez Franco, Andrea / Joven Maried, Jorge / París Sans, Marta
    Keywords: Weight loss Polyunsaturated fatty acids Metaflammation Lipoxygenase Cyclooxygenase Bariatric surgery Adipose lipid turnover weight loss polyunsaturated fatty acids meta flammation macrophage polarization lipoxygenase health fatty-acids disease cyclooxygenase bariatric surgery adiponectin activation
    Abstract: The relationship between lipid mediators and severe obesity remains unclear. Our study investigates the impact of severe obesity on plasma concentrations of oxylipins and fatty acids and explores the consequences of weight loss.In the clinical trial identifier NCT05554224 study, 116 patients with severe obesity and 63 overweight/obese healthy controls matched for age and sex (≈2:1) provided plasma. To assess the effect of surgically induced weight loss, we requested paired plasma samples from 44 patients undergoing laparoscopic sleeve gastrectomy one year after the procedure. Oxylipins were measured using ultra-high-pressure liquid chromatography coupled to a triple quadrupole mass spectrometer via semi-targeted lipidomics. Cytokines and markers of interorgan crosstalk were measured using enzyme-linked immunosorbent assays.We observed significantly elevated levels of circulating fatty acids and oxylipins in patients with severe obesity compared to their metabolically healthier overweight/obese counterparts. Our findings indicated that sex and liver disease were not confounding factors, but we observed weak correlations in plasma with circulating adipokines, suggesting the influence of adipose tissue. Importantly, while weight loss restored the balance in circulating fatty acids, it did not fully normalize the oxylipin profile. Before surgery, oxylipins derived from lipoxygenase activity, such as 12-HETE, 11-HDoHE, 14-HDoHE, and 12-HEPE, were predominant. However, one year following laparoscopic sleeve gastrectomy, we observed a complex shift in the oxylipin profile, favoring species from the cyclooxygenase pathway, particularly proinflammatory prostanoids like TXB2, PGE2, PGD2, and 12-HHTrE. This transformation appears to be linked to a reduction in adiposity, underscoring the role of lipid turnover in the development of metabolic disorders associated with severe obesity.Despite the reduction in fatty acid levels associated with weight loss, the oxylipin profile shifts towards a predominance of more proinflammatory species. These observations underscore the significance of seeking mechanistic approaches to address severe obesity and emphasize the importance of closely monitoring the metabolic adaptations after weight loss.Copyright © 2023 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: andrea.jimenez@urv.cat marta.paris@urv.cat jorge.camps@urv.cat danieldel.castillo@urv.cat helena.castane@estudiants.urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat
    Author identifier: 0000-0002-3165-3640 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-0815-2570 0000-0003-2749-4541
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(23)00424-7/fulltext#%20
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Nutrition. 43 (1): 246-258
    APA: Jiménez-Franco, A; Castañé, H; Martínez-Navidad, C; Placed-Gallego, C; Hernández-Aguilera, A; Fernández-Arroyo, S; Samarra, I; Canela-Capdevila, M; Ar (2024). Metabolic adaptations in severe obesity: Insights from circulating oxylipins before and after weight loss. Clinical Nutrition, 43(1), 246-258. DOI: 10.1016/j.clnu.2023.12.002
    Article's DOI: 10.1016/j.clnu.2023.12.002
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Weight loss
    Polyunsaturated fatty acids
    Metaflammation
    Lipoxygenase
    Cyclooxygenase
    Bariatric surgery
    Adipose lipid turnover
    weight loss
    polyunsaturated fatty acids
    meta flammation
    macrophage polarization
    lipoxygenase
    health
    fatty-acids
    disease
    cyclooxygenase
    bariatric surgery
    adiponectin
    activation
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar