Articles producció científica> Psicologia

A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets

  • Identification data

    Identifier: imarina:9334943
    Authors:
    Biosca-Brull, JOna, GAlarcon-Franco, LColomina, MT
    Abstract:
    Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects are still not defined. This study aims to identify changes in gene expression induced by a single oral dose of IBO in the cortex of mice by means of a transcriptomic analysis for the first time. Our results showed significant alterations in gene expression in mouse frontal cortex samples 4 h after a single oral dose of IBO. Specifically, genes involved in hormonal pathways and synaptogenesis exhibited upregulation, while genes associated with apoptotic processes and endosomal transports showed downregulation. The findings were further corroborated through quantitative polymerase chain reaction (qPCR) analysis. However, the validation of gene expression related to hormonal pathways did not entirely align with the transcriptomic analysis results, possibly due to the brain region from which tissue was collected. Sex differences were observed, with female mice displaying more pronounced alterations in gene expression after IBO treatment. High variability was observed across individual animals. However, this study represents a significant advancement in comprehending IBO's molecular actions. The findings highlight the influence of IBO on gene expression, particularly on hormonal pathways, synaptogenesis, apoptotic processes, and endosomal transports. The identification of sex differences underscores the importance of considering sex as a potential factor influencing IBO's effects. Further research to assess different time points after IBO exposure is warranted.© 2024. The Author(s).
  • Others:

    Author, as appears in the article.: Biosca-Brull, J; Ona, G; Alarcon-Franco, L; Colomina, MT
    Department: Antropologia, Filosofia i Treball Social Psicologia
    URV's Author/s: Biosca Brull, Judit / Colomina Fosch, Maria Teresa / Oña Esteve, Genís
    Keywords: Naloxone-precipitated withdrawal vasopressin rats oxytocin morphine-withdrawal lysergic-acid diethylamide gene-expression cell-proliferation brain addiction drug ibogaine
    Abstract: Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects are still not defined. This study aims to identify changes in gene expression induced by a single oral dose of IBO in the cortex of mice by means of a transcriptomic analysis for the first time. Our results showed significant alterations in gene expression in mouse frontal cortex samples 4 h after a single oral dose of IBO. Specifically, genes involved in hormonal pathways and synaptogenesis exhibited upregulation, while genes associated with apoptotic processes and endosomal transports showed downregulation. The findings were further corroborated through quantitative polymerase chain reaction (qPCR) analysis. However, the validation of gene expression related to hormonal pathways did not entirely align with the transcriptomic analysis results, possibly due to the brain region from which tissue was collected. Sex differences were observed, with female mice displaying more pronounced alterations in gene expression after IBO treatment. High variability was observed across individual animals. However, this study represents a significant advancement in comprehending IBO's molecular actions. The findings highlight the influence of IBO on gene expression, particularly on hormonal pathways, synaptogenesis, apoptotic processes, and endosomal transports. The identification of sex differences underscores the importance of considering sex as a potential factor influencing IBO's effects. Further research to assess different time points after IBO exposure is warranted.© 2024. The Author(s).
    Thematic Areas: Saúde coletiva Psychiatry and mental health Psychiatry Psicología Nutrição Medicina ii Medicina i Linguística e literatura Interdisciplinar Engenharias iv Enfermagem Educação física Ciências biológicas ii Ciências biológicas i Cellular and molecular neuroscience Biotecnología Biological psychiatry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: genis.ona@urv.cat genis.ona@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat mariateresa.colomina@urv.cat
    Author identifier: 0000-0002-5619-4874
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41398-024-02773-7
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Translational Psychiatry. 14 (1): 41-41
    APA: Biosca-Brull, J; Ona, G; Alarcon-Franco, L; Colomina, MT (2024). A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets. Translational Psychiatry, 14(1), 41-41. DOI: 10.1038/s41398-024-02773-7
    Article's DOI: 10.1038/s41398-024-02773-7
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Biological Psychiatry,Cellular and Molecular Neuroscience,Psychiatry,Psychiatry and Mental Health
    Naloxone-precipitated withdrawal
    vasopressin
    rats
    oxytocin
    morphine-withdrawal
    lysergic-acid diethylamide
    gene-expression
    cell-proliferation
    brain
    addiction drug ibogaine
    Saúde coletiva
    Psychiatry and mental health
    Psychiatry
    Psicología
    Nutrição
    Medicina ii
    Medicina i
    Linguística e literatura
    Interdisciplinar
    Engenharias iv
    Enfermagem
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cellular and molecular neuroscience
    Biotecnología
    Biological psychiatry
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