Author, as appears in the article.: Benaiges, Ester; Ceperuelo-Mallafre, Victoria; Guaita, Sandra; Maymo-Masip, Elsa; Madeira, Ana; Gomez, David; Hernandez, Victor; Vilaseca, Isabel; Merma, Carla; Leon, Xavier; Terra, Ximena; Vendrell, Joan; Aviles-Jurado, Francesc Xavier; Fernandez-Veledo, Sonia
Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
URV's Author/s: Avilés Jurado, Francisco Javier / Benaiges Moragrega, Ester / Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Gómez Gómez, David / GUAITA ESTERUELAS, SANDRA / Hernandez Masgrau, Victor / Maymo Masip, Elsa / Merma Linares, Carla Vanessa / Terra Barbadora, Ximena / Vendrell Ortega, Juan José
Keywords: Therapeutic target Survivin Squamous cell carcinoma of head and neck Radiotherapy Radioresistance Radiation tolerance Prognosis Middle aged Male Inhibitor of apoptosis proteins Humans Hnscc Head and neck neoplasms Glucose metabolism Glucose Female Disease-free survival Cell line, tumor Carcinoma, squamous cell Birc5 protein, human Biomarkers, tumor Aged Adult survivin radiotherapy radioresistance radiation hnscc expression cancer-cells apoptosis
Abstract: Metabolic reprogramming and abnormal glucose metabolism are hallmarks of head and neck squamous cell carcinoma (HNSCC). Certain oncogenes can promote cancer-related metabolic changes, but understanding their crosstalk in HNSCC biology and treatment is essential for identifying predictive biomarkers and developing target therapies.We assessed the value of survivin/BIRC5 as a radioresistance factor potentially modulated by glucose for predicting therapeutic sensitivity and prognosis of HNSCC in a cohort of 32 patients. Additionally, we conducted in vitro experiments to explore the role of survivin/BIRC5 in glucose metabolism concerning radiation response.Tumoral BIRC5 expression is associated with serum glucose and predicts locoregional disease-free survival and lower BIRC5 mRNA levels are associated with better outcomes. Upregulation of BIRC5 by radiation depends on glucose levels and provokes a pro-tumoral and radioresistant phenotype in surviving cells.Survivin/BIRC5 might be independently associated with the risk of recurrence in patients with HNSCC.© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.
Thematic Areas: Surgery Saúde coletiva Otorhinolaryngology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: david.gomez@urv.cat victor.hernandez@urv.cat carlavanessa.merma@urv.cat elsa.maymo@urv.cat victoria.ceperuelo@urv.cat franciscojavier.aviles@urv.cat carlavanessa.merma@urv.cat ester.benaiges@estudiants.urv.cat ester.benaiges@estudiants.urv.cat sonia.fernandez@urv.cat ximena.terra@urv.cat juanjose.vendrell@urv.cat
Author identifier: 0000-0003-3770-8486 0000-0002-9133-3120 0000-0002-4460-9761 0000-0001-5560-8097 0000-0003-2906-3788 0000-0003-1043-5844 0000-0002-6994-6115
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/hed.27651
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 46 (7): 1752-1765
APA: Benaiges, Ester; Ceperuelo-Mallafre, Victoria; Guaita, Sandra; Maymo-Masip, Elsa; Madeira, Ana; Gomez, David; Hernandez, Victor; Vilaseca, Isabel; Mer (2024). Survivin/BIRC5 as a novel molecular effector at the crossroads of glucose metabolism and radioresistance in head and neck squamous cell carcinoma. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 46(7), 1752-1765. DOI: 10.1002/hed.27651
Article's DOI: 10.1002/hed.27651
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV