Articles producció científica> Medicina i Cirurgia

Survivin/BIRC5 as a novel molecular effector at the crossroads of glucose metabolism and radioresistance in head and neck squamous cell carcinoma

  • Identification data

    Identifier: imarina:9362471
  • Authors:

    Benaiges, E
    Ceperuelo-Mallafré, V
    Guaita, S
    Maymó-Masip, E
    Madeira, A
    Gómez, D
    Hernández, V
    Vilaseca, I
    Merma, C
    León, X
    Terra, X
    Vendrell, J
    Avilés-Jurado, FX
    Fernández-Veledo, S
  • Others:

    Author, as appears in the article.: Benaiges, E; Ceperuelo-Mallafré, V; Guaita, S; Maymó-Masip, E; Madeira, A; Gómez, D; Hernández, V; Vilaseca, I; Merma, C; León, X; Terra, X; Vendrell, J; Avilés-Jurado, FX; Fernández-Veledo, S
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    URV's Author/s: Avilés Jurado, Francisco Javier / Benaiges Moragrega, Ester / Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Gómez Gómez, David / GUAITA ESTERUELAS, SANDRA / Hernandez Masgrau, Victor / Maymo Masip, Elsa / Merma Linares, Carla Vanessa / Terra Barbadora, Ximena / Vendrell Ortega, Juan José
    Keywords: Therapeutic target Survivin Radiotherapy Radioresistance Hnscc Glucose metabolism survivin radiotherapy radioresistance radiation hnscc expression cancer-cells apoptosis
    Abstract: Metabolic reprogramming and abnormal glucose metabolism are hallmarks of head and neck squamous cell carcinoma (HNSCC). Certain oncogenes can promote cancer-related metabolic changes, but understanding their crosstalk in HNSCC biology and treatment is essential for identifying predictive biomarkers and developing target therapies.We assessed the value of survivin/BIRC5 as a radioresistance factor potentially modulated by glucose for predicting therapeutic sensitivity and prognosis of HNSCC in a cohort of 32 patients. Additionally, we conducted in vitro experiments to explore the role of survivin/BIRC5 in glucose metabolism concerning radiation response.Tumoral BIRC5 expression is associated with serum glucose and predicts locoregional disease-free survival and lower BIRC5 mRNA levels are associated with better outcomes. Upregulation of BIRC5 by radiation depends on glucose levels and provokes a pro-tumoral and radioresistant phenotype in surviving cells.Survivin/BIRC5 might be independently associated with the risk of recurrence in patients with HNSCC.© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.
    Thematic Areas: Surgery Saúde coletiva Otorhinolaryngology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: sonia.fernandez@urv.cat david.gomez@urv.cat victor.hernandez@urv.cat carlavanessa.merma@urv.cat elsa.maymo@urv.cat victoria.ceperuelo@urv.cat franciscojavier.aviles@urv.cat juanjose.vendrell@urv.cat ximena.terra@urv.cat ester.benaiges@estudiants.urv.cat ester.benaiges@estudiants.urv.cat carlavanessa.merma@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0003-3770-8486 0000-0002-9133-3120 0000-0002-4460-9761 0000-0001-5560-8097 0000-0002-6994-6115 0000-0003-1043-5844
    Record's date: 2024-06-22
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/hed.27651
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 46 (7): 1752-1765
    APA: Benaiges, E; Ceperuelo-Mallafré, V; Guaita, S; Maymó-Masip, E; Madeira, A; Gómez, D; Hernández, V; Vilaseca, I; Merma, C; León, X; Terra, X; Vendrell, (2024). Survivin/BIRC5 as a novel molecular effector at the crossroads of glucose metabolism and radioresistance in head and neck squamous cell carcinoma. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 46(7), 1752-1765. DOI: 10.1002/hed.27651
    Article's DOI: 10.1002/hed.27651
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Otorhinolaryngology,Surgery
    Therapeutic target
    Survivin
    Radiotherapy
    Radioresistance
    Hnscc
    Glucose metabolism
    survivin
    radiotherapy
    radioresistance
    radiation
    hnscc
    expression
    cancer-cells
    apoptosis
    Surgery
    Saúde coletiva
    Otorhinolaryngology
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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