Author, as appears in the article.: Tobajas, Y; Alemany-Fornés, M; Samarra, I; Romero-Giménez, J; Cuñé-Castellana, J; Tintoré, M; del Pino, A; Canela, N; del Bas, JM; Ortega-Olivé, N; de Lecea, C; Escoté, X
Department: Bioquímica i Biotecnologia
URV's Author/s: Alemany Fornes, Marc / Escote Miro, Xavier / Samarra Mestre, Iris
Keywords: Symptoms Psychotropic Pregabalin Management Histamine intolerance Histamine Gamma-aminobutyric-acid Fibromyalgia Double-blind Dao Caco-2 cells
Abstract: Background: Histamine intolerance manifests when there is an imbalance between the production of histamine and the body's capacity to metabolise it. Within the gastrointestinal tract, diamine oxidase (DAO) plays a pivotal role in breaking down ingested histamine. Insufficient levels of DAO have been linked to various diseases affecting the respiratory, cardiovascular, nervous, muscular, and digestive systems; some of these symptoms are evidenced in fibromyalgia syndrome. This underscores the crucial role of DAO in maintaining the histamine balance and highlights its association with diverse physiological systems and health conditions. The management of fibromyalgia commonly involves the use of psychotropic medications; however, their potential interactions with DAO remain not fully elucidated. Methods: This study delved into the influence of various psychotropic medications on DAO activity through in vitro experiments. Additionally, we explored their impact on the human intestinal cell line Caco-2, examining alterations in DAO expression at both the mRNA and protein levels along with DAO activity. Results: Notably, the examined drugs-sertraline, pregabalin, paroxetine, alprazolam, and lorazepam-did not exhibit inhibitory effects on DAO activity or lead to reductions in DAO levels. In contrast, citalopram demonstrated a decrease in DAO activity in in vitro assays without influencing DAO levels and activity in human enterocytes. Conclusions: These findings imply that a collaborative approach involving psychotropic medications and DAO enzyme supplementation for individuals with fibromyalgia and a DAO deficiency could offer potential benefits for healthcare professionals in their routine clinical practice.
Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: xavier.escote@urv.cat marc.alemany@estudiants.urv.cat iris.samarra@estudiants.urv.cat iris.samarra@estudiants.urv.cat
Author identifier: 0000-0003-1172-3995 0000-0001-5257-8398
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2077-0383/13/3/792
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Clinical Medicine. 13 (3):
APA: Tobajas, Y; Alemany-Fornés, M; Samarra, I; Romero-Giménez, J; Cuñé-Castellana, J; Tintoré, M; del Pino, A; Canela, N; del Bas, JM; Ortega-Olivé, N; de (2024). Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with Citalopram. Journal Of Clinical Medicine, 13(3), -. DOI: 10.3390/jcm13030792
Article's DOI: 10.3390/jcm13030792
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications