Author, as appears in the article.: Hernandez-Pinilla, Alba; Clua-Espuny, Jose-Luis; Satue-Gracia, Eva Maria; Palleja-Millan, Meritxell; Martin-Lujan, Francisco M
Department: Medicina i Cirurgia
URV's Author/s: Martín Lujan, Francisco Manuel
Keywords: Stroke Score Prospective studies Primary prevention Primary health care Primary care Prediction Population Multicenter studies as topic Humans Follow-up studies Early diagnosis Dementia Cognitive dysfunction Cardiology Biomarkers Atrial fibrillation Association Af
Abstract: Background Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. Future estimations suggest an increase in global burden of AF greater than 60% by 2050. Numerous studies provide growing evidence that AF is not only associated with stroke but also with cognitive impairment and dementia.Aim The main goal is to assess the impact of the combined use of cardiac rhythm monitoring devices, echocardiography, biomarkers and neuroimaging on the early diagnosis of AF, silent strokes and cognitive decline, in subjects at high risk of AF.Methods and analysis Two-year follow-up of a cohort of individuals aged 65-85 years at high risk for AF, with no prior diagnosis of either stroke or dementia. The study involves baseline echocardiography, biomarkers, and neuroimaging, yearly cardiac monitoring, and semiannual clinical assessments. Different parameters from these tests will be analysed as independent variables. Throughout the study period, primary outcomes: new diagnoses of AF, stroke and cognitive impairment, along with any clinical and therapeutic changes, will be registered. A first descriptive and bivariate statistical analysis, appropriate to the types of variables, will be done. The information obtained from the data analysis will encompass adjusted risk estimates along with 95% confidence intervals. Event risk predictions will rely on multivariate Cox proportional hazards regression models. The predictive value of the model will be evaluated through the utilisation of receiver operating characteristic curves for area under the curve calculation. Additionally, time-to-event analysis will be performed using Kaplan-Meier curves.Ethics and dissemination This study protocol has been reviewed and approved by the Independent Ethics Committee of the Foundation University Institute for Primary Health Care Research-IDIAP Jordi Gol (expedient file 22/090-P). The authors plan to disseminate the study results to the general public through various scientific events. Publication in open-access journals and presentations at scientific congresses, seminars and meetings is also foreseen.Trial registration number NCT05772806.
Thematic Areas: Saúde coletiva Psicología Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: paco.martin@urv.cat
Author identifier: 0000-0003-0359-3588
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/submittedVersion
Paper original source: Bmj Open. 14 (2): e080736-
APA: Hernandez-Pinilla, Alba; Clua-Espuny, Jose-Luis; Satue-Gracia, Eva Maria; Palleja-Millan, Meritxell; Martin-Lujan, Francisco M (2024). Protocol for a multicentre and prospective follow-up cohort study of early detection of atrial fibrillation, silent stroke and cognitive impairment in high-risk primary care patients: the PREFA-TE study. Bmj Open, 14(2), e080736-. DOI: 10.1136/bmjopen-2023-080736
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: info:eu-repo/semantics/preprint
Repositori URV