Author, as appears in the article.: Pàmies A; Llop D; Ibarretxe D; Rosales R; Masana L; Vallvé JC; Paredes S
Department: Medicina i Cirurgia
URV's Author/s: Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Paredes Gonzalez-Albo, Silvia Remedios / ROSALES RIBAS, ROSER / Vallvé Torrente, Joan Carles
Keywords: Rheumatoid arthritis Plaque presence Inflammation Growth factors Biomarker Atherosclerosis
Abstract: Introduction: Patients with RA are at a higher risk of developing CV diseases than the general population. The precise mechanisms are still unknown. We evaluated the associations between 8 plasma growth factors (GFs) (angiopoietin-2, EGF, HB-EGF, PLGF, TGF-α, VEGFa, VEGFc, and VEGFd) and subclinical arteriosclerosis in RA patients. Materials and methods: A total of 199 patients with RA treated at the Hospital Universitari Sant Joan de Reus (Spain) between 2011 and 2015 were included in this cross-sectional study. Carotid intima media thickness (cIMT), carotid plaque presence (cPP) and pulse wave velocity (PWV) were measured. GFs were measured with Bio-Plex Pro Human Cancer Biomarker Panel 2 (Bio-Rad). Multivariate models and partial least square discriminant analysis (PLS-DA) were used for analysis (RStudio, version 4.0.1). Results: Multivariate models showed that angiopoietin-2 was associated with cPP and PWV in the overall cohort (OR = 1.53 and β = 0.20, respectively). VEGFc (β = 0.29), VEGFa (β = 0.26) and HB-EGF (β = 0.22) were also associated with PWV. VEGFa (OR = 2.36), VEGFd (OR = 2.29), EGF (OR = 2.62), PLGF (OR = 2.54), and HB-EGF (OR = 2.24) were associated with cPP in men. According to PLS-DA, GFs were able to distinguish between patients with and without cPP in the overall cohort, male cohort, and female cohort. In women, angiopoietin-2 was associated with PWV (β = 0.18). Conclusions: The selected GFs were closely related to atherosclerosis in patients with RA and are potential predictors of CV disease in patients with RA.
Thematic Areas: Structural biology Medicina i Genetics Computer science applications Ciências biológicas ii Ciências biológicas i Biotecnología Biotechnology Biophysics Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: didac.llop@urv.cat silviaremedios.paredes@urv.cat daiana.ibarretxe@urv.cat jc.vallve@urv.cat didac.llop@urv.cat jc.vallve@urv.cat luis.masana@urv.cat
Author identifier: 0000-0002-0789-4954
Record's date: 2024-09-21
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.csbj.org/article/S2001-0370(24)00125-9/fulltext
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Computational And Structural Biotechnology Journal. 23 1680-1688
APA: Pàmies A; Llop D; Ibarretxe D; Rosales R; Masana L; Vallvé JC; Paredes S (2024). Angiopoietin-2, vascular endothelial growth factor family, and heparin binding endothelial growth factor are associated with subclinical atherosclerosis in rheumatoid arthritis. Computational And Structural Biotechnology Journal, 23(), 1680-1688. DOI: 10.1016/j.csbj.2024.04.042
Article's DOI: 10.1016/j.csbj.2024.04.042
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV