Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

Identifier:  imarina:9371410

Handle: https://hdl.handle.net/20.500.11797/imarina9371410

Authors:  Khoury, Nadine; Martinez, Maria Angeles; Nishi, Stephanie K...

Abstract:
Background: Endocrine disruptors (EDs) have emerged as potential contributors to the development of type -2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. Objective: To assess at baseline and after 1 -year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body -mass -index (BMI) in a senior population of 4600 nondiabetic participants from the PREDIMED-plus study. Methods: Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI. Results: Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [ beta -coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p -trend