Articles producció científica> Bioquímica i Biotecnologia

Photoperiod effects on corticosterone and seasonal clocks in cafeteria-induced obese fischer 344 rats are influenced by gut microbiota.

  • Identification data

    Identifier: imarina:9384571
    Authors:
    Arreaza-Gil VEscobar-Martínez ISoliz-Rueda JRSuárez MMuguerza BSchellekens HTorres-Fuentes CArola-Arnal A
    Abstract:
    Seasonal rhythms are gaining attention given their impact on metabolic disorders development such as obesity gut microbiota is emerging as a key factor in mediating this link. However, the underlying mechanisms are still poorly understood. In this regard, corticosterone may play a role as it has been shown to be affected by gut bacteria and seasonal rhythms, and has been linked to obesity. Thus, this study aimed to investigate if seasonal rhythms effects on corticosterone are influenced by gut microbiota in obese rats and whether this may be related to seasonal and clock genes expression in the pituitary gland and colon. Fischer 344 male rats fed with cafeteria diet (CAF) were housed under different photoperiods for 9 weeks and treated with an antibiotic cocktail (ABX) in drinking water during the last 4 weeks. Rats fed with standard chow and CAF-fed rats without ABX were included as controls. ABX altered gut microbiota, corticosterone levels and seasonal clock expression in the pituitary depending on photoperiod conditions. These results suggest a link between gut bacteria, seasonal rhythms and corticosterone and a novel nutrigenomic target for obesity.
  • Others:

    Author, as appears in the article.: Arreaza-Gil V; Escobar-Martínez I; Soliz-Rueda JR; Suárez M; Muguerza B; Schellekens H; Torres-Fuentes C; Arola-Arnal A
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2045-2322
    URV's Author/s: Arola Arnal, Anna / Arreaza Gil, Verónica / Escobar Martínez, Ivan / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Suárez Recio, Manuel / Torres Fuentes, Cristina
    Keywords: Animals Antibiotic Chga Colon Corticosterone Eya3 Gastrointestinal microbiome Male Obesity Photoperiod Pituitary gland Rats Rats, inbred f344 Seasonal rhythms Seasons Western diet
    Abstract: Seasonal rhythms are gaining attention given their impact on metabolic disorders development such as obesity gut microbiota is emerging as a key factor in mediating this link. However, the underlying mechanisms are still poorly understood. In this regard, corticosterone may play a role as it has been shown to be affected by gut bacteria and seasonal rhythms, and has been linked to obesity. Thus, this study aimed to investigate if seasonal rhythms effects on corticosterone are influenced by gut microbiota in obese rats and whether this may be related to seasonal and clock genes expression in the pituitary gland and colon. Fischer 344 male rats fed with cafeteria diet (CAF) were housed under different photoperiods for 9 weeks and treated with an antibiotic cocktail (ABX) in drinking water during the last 4 weeks. Rats fed with standard chow and CAF-fed rats without ABX were included as controls. ABX altered gut microbiota, corticosterone levels and seasonal clock expression in the pituitary depending on photoperiod conditions. These results suggest a link between gut bacteria, seasonal rhythms and corticosterone and a novel nutrigenomic target for obesity.
    Thematic Areas: Astronomia / física Biodiversidade Biotecnología Ciência da computação Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação Educação física Enfermagem Engenharias ii Engenharias iii Engenharias iv Farmacia Geociências Geografía Interdisciplinar Letras / linguística Matemática / probabilidade e estatística Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Multidisciplinary Multidisciplinary sciences Nutrição Odontología Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: cristina.torres@urv.cat begona.muguerza@urv.cat anna.arola@urv.cat manuel.suarez@urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat jorgericardo.soliz@urv.cat ivan.escobar@estudiants.urv.cat
    Author identifier: 0000-0002-2917-6910 0000-0001-7384-8588 0000-0001-6529-1345 0000-0003-0122-8253 0000-0002-8301-2095 0000-0002-8301-2095 0000-0002-8301-2095
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-024-73289-9
    Papper original source: Scientific Reports. 14 (1): 22560-
    APA: Arreaza-Gil V; Escobar-Martínez I; Soliz-Rueda JR; Suárez M; Muguerza B; Schellekens H; Torres-Fuentes C; Arola-Arnal A (2024). Photoperiod effects on corticosterone and seasonal clocks in cafeteria-induced obese fischer 344 rats are influenced by gut microbiota.. Scientific Reports, 14(1), 22560-. DOI: 10.1038/s41598-024-73289-9
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1038/s41598-024-73289-9
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Animals
    Antibiotic
    Chga
    Colon
    Corticosterone
    Eya3
    Gastrointestinal microbiome
    Male
    Obesity
    Photoperiod
    Pituitary gland
    Rats
    Rats, inbred f344
    Seasonal rhythms
    Seasons
    Western diet
    Astronomia / física
    Biodiversidade
    Biotecnología
    Ciência da computação
    Ciência de alimentos
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Economia
    Educação
    Educação física
    Enfermagem
    Engenharias ii
    Engenharias iii
    Engenharias iv
    Farmacia
    Geociências
    Geografía
    Interdisciplinar
    Letras / linguística
    Matemática / probabilidade e estatística
    Materiais
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Multidisciplinary
    Multidisciplinary sciences
    Nutrição
    Odontología
    Psicología
    Química
    Saúde coletiva
    Zootecnia / recursos pesqueiros
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