Phosphoester bond hydrolysis by a discrete zirconium-oxo cluster: mechanistic insights into the central role of the binuclear ZrIV-ZrIV active site

Identifier:  imarina:9388747

Handle: https://hdl.handle.net/20.500.11797/imarina9388747

Authors:  Luiz, E; de Azambuja, F; Solé-Daura, A; Puiggali-Jou, J; Mullaliu, A; Carbó, JJ; Xavier, FR; Peralta, RA; Parac-Vogt, TN

Abstract:
Effective degradation of non-natural phosphate triesters (PTs) widely used in pesticides and warfare agents is of paramount relevance for human and environmental safety, particularly under acidic conditions where they are highly stable. Here, we present a detailed reactivity and mechanistic study pioneering discrete {Zr6O8} clusters, which are commonly employed as building blocks for Zr-MOFs and as non-classical soluble coordination compounds for the degradation of PTs using the pesticide ethyl paraoxon as a model. Combined computational studies, mechanistic experiments, and EXAFS analysis show that the reactivity of these clusters arises from their ZrIV-ZrIV bimetallic sites, which hydrolyze ethyl paraoxon under acidic conditions through an intramolecular pathway. Remarkably, the energetics of the reaction is dependent on the protonation state of the active sites, and a weakly acidic medium favors the reaction. Moreover, catalyst stability allowed for its recovery and reuse. Such a mechanism is in close analogy to enzymatic reactions and different from that previously reported for Zr-MOFs. These findings outline the potential of MIV-MIV active sites for PT degradation under challenging aqueous acidic conditions and contribute to the development of bioinspired catalysts and materials.