Articles producció científica> Enginyeria Química

A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring

  • Identification data

    Identifier: imarina:9389461
    Handle: https://hdl.handle.net/20.500.11797/imarina9389461
    Authors:
    Purece, AnthonyThomsen, Sofie TheresaPlass, DietrichSpyropoulou, AnastasiaMachera, KyriakiPalmont, PhilippeCrepet, AmelieBenchrih, RafiqaDevleesschauwer, BrechtWieland, NinaScheepers, PaulDeepika, DeepikaKumar, VikasSanchez, GerardoBessems, JosPiselli, DarioBuekers, Jurgen
    Abstract:
    Human biomonitoring (HBM) data indicate that exposure to pyrethroids is widespread in Europe, with significantly higher exposure observed in children compared to adults. Epidemiological, toxicological, and mechanistic studies raise concerns for potential human health effects, particularly, behavioral effects such as attention deficit hyperactivity disorder (ADHD) in children at low levels of exposure. Based on an exposure-response function from a single European study and on available quality-assured and harmonized HBM data collected in France, Germany, Iceland, Switzerland, and Israel, a preliminary estimate of the environmental burden of disease for ADHD associated with pyrethroid exposure was made for individuals aged 0-19 years. The estimated annual number of prevalence-based disability-adjusted life years (DALYs) per million inhabitants were 27 DALYs for Israel, 21 DALYs for France, 12 DALYs for both Switzerland and Iceland, and 3 DALYs for Germany; while the annual ADHD cases per million inhabitants attributable to pyrethroids were 2189 for Israel, 1710 for France, 969 for Iceland, 944 for Switzerland, and 209 for Germany. Direct health costs related to ADHD ranged between 0.3 and 2.5 million EUR yearly per million inhabitants for the five countries. Additionally, a substantial number of ADHD cases, on average 18%, were associated with pyrethroid exposure. Yet, these figures should be interpreted with caution given the uncertainty of the estimation. A sensitivity analysis showed that by applying a different exposure-response function from outside the EU, the population attributable fraction decreased from an average of 18 to 7%. To ensure more robust disease burden estimates and adequate follow-up of policy measures, more HBM studies are needed, along with increas

  • Others:

    Author, as appears in the article.: Purece, Anthony; Thomsen, Sofie Theresa; Plass, Dietrich; Spyropoulou, Anastasia; Machera, Kyriaki; Palmont, Philippe; Crepet, Amelie; Benchrih, Rafiqa; Devleesschauwer, Brecht; Wieland, Nina; Scheepers, Paul; Deepika, Deepika; Kumar, Vikas; Sanchez, Gerardo; Bessems, Jos; Piselli, Dario; Buekers, Jurgen
    Department: Enginyeria Química
    URV's Author/s: Kumar, Vikas
    Keywords: Adolescent Adult Attention deficit disorder with hyperactivity Behavioral-problems Biological monitoring Child Child, preschool Children Cohor Cypermethrin Disability-adjusted life years Environmental exposure Environmental monitoring Europe Female Hormone Humans Infant Infant, newborn Insecticides Male Metabolites Pesticides Prenatal exposure Pyrethrins Receptor Risk Young adult
    Abstract: Human biomonitoring (HBM) data indicate that exposure to pyrethroids is widespread in Europe, with significantly higher exposure observed in children compared to adults. Epidemiological, toxicological, and mechanistic studies raise concerns for potential human health effects, particularly, behavioral effects such as attention deficit hyperactivity disorder (ADHD) in children at low levels of exposure. Based on an exposure-response function from a single European study and on available quality-assured and harmonized HBM data collected in France, Germany, Iceland, Switzerland, and Israel, a preliminary estimate of the environmental burden of disease for ADHD associated with pyrethroid exposure was made for individuals aged 0-19 years. The estimated annual number of prevalence-based disability-adjusted life years (DALYs) per million inhabitants were 27 DALYs for Israel, 21 DALYs for France, 12 DALYs for both Switzerland and Iceland, and 3 DALYs for Germany; while the annual ADHD cases per million inhabitants attributable to pyrethroids were 2189 for Israel, 1710 for France, 969 for Iceland, 944 for Switzerland, and 209 for Germany. Direct health costs related to ADHD ranged between 0.3 and 2.5 million EUR yearly per million inhabitants for the five countries. Additionally, a substantial number of ADHD cases, on average 18%, were associated with pyrethroid exposure. Yet, these figures should be interpreted with caution given the uncertainty of the estimation. A sensitivity analysis showed that by applying a different exposure-response function from outside the EU, the population attributable fraction decreased from an average of 18 to 7%. To ensure more robust disease burden estimates and adequate follow-up of policy measures, more HBM studies are needed, along with increased efforts to harmonize the design of epidemiological studies upfront to guarantee meta-analysis of exposure-response functions. This is particularly important for pyrethroids as evidence of potential adverse health effects is continuously emerging.
    Thematic Areas: Astronomia / física Biodiversidade Biotecnología Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Enfermagem Environmental sciences Geociências Health, toxicology and mutagenesis Interdisciplinar Medicina i Medicina ii Medicine (miscellaneous) Public health, environmental and occupational health Public, environmental & occupational health Saúde coletiva
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: vikas.kumar@urv.cat
    Author identifier: 0000-0002-9795-5967
    Record's date: 2024-11-09
    Papper version: info:eu-repo/semantics/publishedVersion
    Papper original source: Environmental Health. 23 (1): 91-
    APA: Purece, Anthony; Thomsen, Sofie Theresa; Plass, Dietrich; Spyropoulou, Anastasia; Machera, Kyriaki; Palmont, Philippe; Crepet, Amelie; Benchrih, Rafiq (2024). A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring. Environmental Health, 23(1), 91-. DOI: 10.1186/s12940-024-01131-w
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications

  • Keywords:

    Environmental Sciences,Health, Toxicology and Mutagenesis,Medicine (Miscellaneous),Public Health, Environmental and Occupational Health,Public, Environmental & Occupational Health
    Adolescent
    Adult
    Attention deficit disorder with hyperactivity
    Behavioral-problems
    Biological monitoring
    Child
    Child, preschool
    Children
    Cohor
    Cypermethrin
    Disability-adjusted life years
    Environmental exposure
    Environmental monitoring
    Europe
    Female
    Hormone
    Humans
    Infant
    Infant, newborn
    Insecticides
    Male
    Metabolites
    Pesticides
    Prenatal exposure
    Pyrethrins
    Receptor
    Risk
    Young adult
    Astronomia / física
    Biodiversidade
    Biotecnología
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Enfermagem
    Environmental sciences
    Geociências
    Health, toxicology and mutagenesis
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicine (miscellaneous)
    Public health, environmental and occupational health
    Public, environmental & occupational health
    Saúde coletiva

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