Major cardiovascular events after COVID-19 in people with HIV

Identifier:  imarina:9389468

Handle: https://hdl.handle.net/20.500.11797/imarina9389468

Authors:  Martin-Iguacel, Raquel; Moreno-Fornes, Sergio; Bruguera, Andreu; Aceiton, Jordi; Kwakye Nomah, Daniel; Gonzalez-Cordon, Ana; Domingo, Pere; Curran, Adrian; Imaz, Arkaitz; Dalmau Juanola, David; Peraire, Joaquim; Borjabad, Beatriz; Arbones Fernandez, Laia; Miro, Jose M; Casabona, Jordi; Llibre, Josep M

Abstract:
Objectives: To assess the effect of COVID-19 on the postacute risk of cardiovascular events (CVEs) among people with HIV (PWH). Methods: Population-based matched cohort, including all PWH >= 16 years in the Catalan PISCIS HIV cohort. We estimated the incidence rate of the first CVE after COVID-19, analysed it a composite outcome (2020-2022). We adjusted for baseline differences using inverse probability weighting and used competing risk analysis. Results: We included 4199 PWH with and 14 004 PWH without COVID-19. The median follow-up was 243 days (interquartile range [IQR]: 93-455), 82% (14 941/18 203) were men, with a median age of 47 years. Overall, 211 PWH with COVID-19 and 621 without developed CVE, with an incidence rate of 70.2 and 56.8/1000 person-years, respectively. During COVID-19 infection, 7.6% (320/4199) required hospitalization and 0.6% (25/4199) intensive care unit admission, 97% (4079/4199) had CD4(+) T-cell >= 200 cells/mL, 90% (3791/4199) had HIV-RNA