Articles producció científica> Psicologia

Gut Microbiota Alterations in Alzheimer's Disease: Relation with Cognitive Impairment and Mediterranean Lifestyle

  • Identification data

    Identifier: imarina:9390038
    Authors:
    Mateo, DavidCarrion, NereaCabrera, CristianHeredia, LuisMarques, MontseForcadell-Ferreres, EvaPino, MariaZaragoza, JosepMoral, AlfonsCavalle, LluisGonzalez-de-Echavarri, Jose MVicens, PalomaDomingo, Jose LTorrente, Margarita
    Abstract:
    Recently, an association between dysbiosis of the gut microbiota (GMB) and the development of several diseases, such as Alzheimer's disease (AD), has been proposed. Dysbiosis involves changes in microbial diversity influenced by environmental factors, like diet or lifestyle. In this study, we investigated the role of GMB parameters in Spanish AD patients, assessing the impact of adherence to the Mediterranean lifestyle (ML), as well as to characterize these parameters in relation to neuropsychological, neuropsychiatric, emotional, and functionality parameters. A case-control study was conducted to investigate the association between the composition of the GMB and cognitive, emotional, neuropsychiatric, and functionality status in Spanish AD patients, along with a shotgun metagenomics approach. Richness and alpha-diversity were significantly lower in the AD group compared to the controls. PERMANOVA and ANOSIM tests of Bray-Curtis dissimilarity, Aitchison distance, and Jaccard similarity did not showed significant differences in beta-diversity between the two groups. Moreover, associations between various phyla of the AD group and orientation performance, food consumption, and activities of daily living were identified. Dysbiosis observed in Spanish AD patients is characterized by reductions in richness and alpha-diversity, alongside alterations in GMB composition, which may be linked to adherence to the ML and cognitive and functionality symptoms.
  • Others:

    Author, as appears in the article.: Mateo, David; Carrion, Nerea; Cabrera, Cristian; Heredia, Luis; Marques, Montse; Forcadell-Ferreres, Eva; Pino, Maria; Zaragoza, Josep; Moral, Alfons; Cavalle, Lluis; Gonzalez-de-Echavarri, Jose M; Vicens, Paloma; Domingo, Jose L; Torrente, Margarita
    Department: Psicologia
    URV's Author/s: Cabrera Marchante, Cristian / Domingo Roig, José Luis / Heredia Santaella, Luis / Marquès Bueno, Montserrat / Mateo García, David / Torrente Torné, Margarita / Vicens Calderón, Paloma
    Keywords: Alzheimer's disease Alzheimer’s disease Anxiet Association Cognition Dementia Gut microbiota Inflammation Microbial diversit Microbial diversity
    Abstract: Recently, an association between dysbiosis of the gut microbiota (GMB) and the development of several diseases, such as Alzheimer's disease (AD), has been proposed. Dysbiosis involves changes in microbial diversity influenced by environmental factors, like diet or lifestyle. In this study, we investigated the role of GMB parameters in Spanish AD patients, assessing the impact of adherence to the Mediterranean lifestyle (ML), as well as to characterize these parameters in relation to neuropsychological, neuropsychiatric, emotional, and functionality parameters. A case-control study was conducted to investigate the association between the composition of the GMB and cognitive, emotional, neuropsychiatric, and functionality status in Spanish AD patients, along with a shotgun metagenomics approach. Richness and alpha-diversity were significantly lower in the AD group compared to the controls. PERMANOVA and ANOSIM tests of Bray-Curtis dissimilarity, Aitchison distance, and Jaccard similarity did not showed significant differences in beta-diversity between the two groups. Moreover, associations between various phyla of the AD group and orientation performance, food consumption, and activities of daily living were identified. Dysbiosis observed in Spanish AD patients is characterized by reductions in richness and alpha-diversity, alongside alterations in GMB composition, which may be linked to adherence to the ML and cognitive and functionality symptoms.
    Thematic Areas: Microbiology Microbiology (medical) Virology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: margarita.torrente@urv.cat joseluis.domingo@urv.cat david.mateo@urv.cat cristian.cabrera@estudiants.urv.cat luis.heredia@urv.cat paloma.vicens@urv.cat luis.heredia@urv.cat
    Author identifier: 0000-0002-8901-6345 0000-0001-6647-9470 0000-0001-9330-9418 0000-0003-0732-5070 0000-0001-9330-9418
    Record's date: 2024-11-16
    Papper version: info:eu-repo/semantics/publishedVersion
    Papper original source: Microorganisms. 12 (10): 2046-
    APA: Mateo, David; Carrion, Nerea; Cabrera, Cristian; Heredia, Luis; Marques, Montse; Forcadell-Ferreres, Eva; Pino, Maria; Zaragoza, Josep; Moral, Alfons; (2024). Gut Microbiota Alterations in Alzheimer's Disease: Relation with Cognitive Impairment and Mediterranean Lifestyle. Microorganisms, 12(10), 2046-. DOI: 10.3390/microorganisms12102046
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Microbiology,Microbiology (Medical),Virology
    Alzheimer's disease
    Alzheimer’s disease
    Anxiet
    Association
    Cognition
    Dementia
    Gut microbiota
    Inflammation
    Microbial diversit
    Microbial diversity
    Microbiology
    Microbiology (medical)
    Virology
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