Predictors of poor health-related quality of life among people living with HIV aged ≥60 years in the PISCIS cohort: Findings from the Vive plus project

Identifier:  imarina:9441862

Handle: https://hdl.handle.net/20.500.11797/imarina9441862

Authors:  Bruguera, Andreu; Egea-Cortes, L; Mesias-Gazmuri, J; Palacio -Vieira, J; Forero, C G; Miranda, C; Saumoy, M; Fernandez, E; Navarro, G; Orti, A; Miro, J M; Casabona, J; Reyes-Uruena, J

Abstract:
Introduction: Advancements in and accessibility to effective antiretroviral therapy has improved the life expectancy of people living with HIV, increasing the proportion of people living with HIV reaching older age (>= 60 years), making this population's health-related quality of life (HRQoL) more relevant. Our aim was to identify the determinants of poor HRQoL in people living with HIV aged >= 60 years and compare them with those of their younger counterparts.Methods: We used data from the 'Vive+' study, a cross-sectional survey conducted between October 2019 and March 2020, nested within the PISCIS cohort of people living with HIV in Catalonia and the Balearic Islands, Spain. We used the 12-item short-form survey (SF-12), divided into a physical component summary (PCS) and a mental component summary (MCS), to evaluate HRQoL. We used the least absolute shrinkage and selection operator for variable selection and used multivariable regression models to identify predictors.Results: Of the 1060 people living with HIV (78.6% males) who participated in the study, 209 (19.7%) were aged >= 60 years. When comparing older people living with HIV (>= 60 years) and their younger counterparts, older people exhibited a worse PCS (median 51.3 [interquartile range {IQR} 46.0-58.1] vs. 46.43 [IQR 42.5-52.7], p < 0.001) but a similar MCS (median 56.0 [IQR 49.34-64.7] vs. 57.0 [IQR 48.9-66.3], p = 0.476). In the multivariable analysis, cognitive function correlated with a PCS (beta correlation factor [beta] -0.18, p = 0.014), and depressive symptoms and satisfaction with social role correlated with an MCS (beta 0.61 and beta -0.97, respectively, p < 0.001) in people living with HIV aged >= 60 years.Conclusion: Depressive symptoms, poor cognitive function, and lower satisfaction with social roles predict poorer HRQoL in older people living with HIV. These factors need to be considered when designing targeted interventions.