Articles producció científica> Bioquímica i Biotecnologia

Dietary Glycemic Index and Load and Semen Quality: ACross-Sectional and Prospective Analysis within the FERTINUTS Trial

  • Identification data

    Identifier: imarina:9443117
    Authors:
    Mateu-Fabregat, JavierPapandreou, ChristopherGutierrez-Tordera, LaiaRojas, MelinaNovau-Ferre, NilMostafa, HamzaBullo, Monica
    Abstract:
    Purpose: Infertility is a global health issue and nutrition plays a significant role in fertility outcomes. We aimed to investigate the cross-sectional and prospective associations of glycemic index (GI) and glycemic load (GL) with semen quality parameters in a cohort of healthy young men. Materials and Methods: The study included 106 men aged 18-35 years from the FERTINUTS trial. Dietary intake was estimated through 3-day dietary records and several semen parameters were assessed. Multivariable linear regression analysis with the Least Absolute Shrinkage and Selection Operator (LASSO) approach was employed. Results: The cross-sectional analysis revealed positive associations between GI and GL and total sperm count, sperm concentration, and total motility. In the prospective analysis, baseline GI was associated with increases in pH, vitality, immotile sperm or abnormal midpiece and decreases in total sperm count and motility. Conversely, GL was positively associated with changes in vitality and total sperm count. Conclusions: While these findings suggest that GI may have adverse effects on several sperm quality parameters, the results were not consistently observed in the cross-sectional analysis. However, GL was consistently associated with better sperm quality in both analyses. The impact of carbohydrate quality and quantity on fertility remains uncertain and larger prospective studies are needed.
  • Others:

    Author, as appears in the article.: Mateu-Fabregat, Javier; Papandreou, Christopher; Gutierrez-Tordera, Laia; Rojas, Melina; Novau-Ferre, Nil; Mostafa, Hamza; Bullo, Monica
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica
    Keywords: Semen analysis Semen analysi Glycemic load Glycemic index Fertility Carbohydrates
    Abstract: Purpose: Infertility is a global health issue and nutrition plays a significant role in fertility outcomes. We aimed to investigate the cross-sectional and prospective associations of glycemic index (GI) and glycemic load (GL) with semen quality parameters in a cohort of healthy young men. Materials and Methods: The study included 106 men aged 18-35 years from the FERTINUTS trial. Dietary intake was estimated through 3-day dietary records and several semen parameters were assessed. Multivariable linear regression analysis with the Least Absolute Shrinkage and Selection Operator (LASSO) approach was employed. Results: The cross-sectional analysis revealed positive associations between GI and GL and total sperm count, sperm concentration, and total motility. In the prospective analysis, baseline GI was associated with increases in pH, vitality, immotile sperm or abnormal midpiece and decreases in total sperm count and motility. Conversely, GL was positively associated with changes in vitality and total sperm count. Conclusions: While these findings suggest that GI may have adverse effects on several sperm quality parameters, the results were not consistently observed in the cross-sectional analysis. However, GL was consistently associated with better sperm quality in both analyses. The impact of carbohydrate quality and quantity on fertility remains uncertain and larger prospective studies are needed.
    Thematic Areas: Urology & nephrology Urology Reproductive medicine Public health, environmental and occupational health Psychiatry and mental health Pharmacology (medical) Health policy Educação física Andrology Aging
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.bullo@urv.cat
    Author identifier: 0000-0002-0218-7046
    Record's date: 2025-02-19
    Paper version: info:eu-repo/semantics/publishedVersion
    Paper original source: World Journal Of Mens Health. 42 (4): 881-889
    APA: Mateu-Fabregat, Javier; Papandreou, Christopher; Gutierrez-Tordera, Laia; Rojas, Melina; Novau-Ferre, Nil; Mostafa, Hamza; Bullo, Monica (2024). Dietary Glycemic Index and Load and Semen Quality: ACross-Sectional and Prospective Analysis within the FERTINUTS Trial. World Journal Of Mens Health, 42(4), 881-889. DOI: 10.5534/wjmh.230328
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Aging,Andrology,Health Policy,Pharmacology (Medical),Psychiatry and Mental Health,Public Health, Environmental and Occupational Health,Reproductive Medicine,Urology,Urology & Nephrology
    Semen analysis
    Semen analysi
    Glycemic load
    Glycemic index
    Fertility
    Carbohydrates
    Urology & nephrology
    Urology
    Reproductive medicine
    Public health, environmental and occupational health
    Psychiatry and mental health
    Pharmacology (medical)
    Health policy
    Educação física
    Andrology
    Aging
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