Recent advances in precision nutrition and cardiometabolic diseases

Identifier:  imarina:9444973

Handle: https://hdl.handle.net/20.500.11797/imarina9444973

Authors:  Martínez-González MA; Planes FJ; Ruiz-Canela M; Toledo E; Estruch R; Salas-Salvadó J; Valdés-Más R; Mena P; Castañer O; Fitó M; Clish C; Landberg R; Wittenbecher C; Liang L; Guasch-Ferré M; Lamuela-Raventós RM; Wang DD; Forouhi N; Razquin C; Hu FB

Abstract:
A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.