Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

Identifier:  imarina:9446330

Handle: https://hdl.handle.net/20.500.11797/imarina9446330

Authors:  Cadman, Tim; Elhakeem, Ahmed; Vinther, Johan Lerbech; Avraam, Demetris; Carrasco, Paula; Calas, Lucinda; Cardol, Marloes; Charles, Marie-Aline; Corpeleijn, Eva; Crozier, Sarah; de Castro, Montserrat; Estarlich, Marisa; Fernandes, Amanda; Fossatti, Serena; Gruszfeld, Dariusz; Guerlich, Kathrin; Grote, Veit; Haakma, Sido; Harris, Jennifer R; Huang, Rae-Chi; Ibarluzea, Jesus; Inskip, Hazel; Jaddoe, Vincent; Koletzko, Berthold; Lioret, Sandrine; Luque, Veronica; Manios, Yannis; Moirano, Giovenale; Moschonis, George; Nieuwenhuijsen, Mark; Andersen, Anne-Marie Nybo; de Moira, Angela Pinot; Popovic, Maja; Roumeliotaki, Theano; Salika, Theodosia; Santa Marina, Loreto; Santos, Susana; Serbert, Sylvain; Tzorovili, Evangelia; Verduci, Elvira; Vrijheid, Martine; Vrijkotte, T G M; Welten, Marieke; Wright, John; Yang, Tiffany C; Zugna, Daniela; Lawlor, Deborah

Abstract:
International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.