Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis

Identifier:  imarina:9446967

Handle: https://hdl.handle.net/20.500.11797/imarina9446967

Authors:  Bosco, Giosiana; Barbagallo, Francesco Di Giacomo; Di Marco, Maurizio; Scilletta, Sabrina; Miano, Nicoletta; Capuccio, Stefania; Musmeci, Marco; Di Mauro, Stefania; Filippello, Agnese; Scamporrino, Alessandra; Di Pino, Antonino; Masana, Luis; Purrello, Francesco; Piro, Salvatore; Scicali, Roberto

Abstract:
Background: Familial hypercholesterolemia (FH) is a genetic condition characterized by high low-density lipoprotein cholesterol (LDL-C). The presence of risk modifiers could promote the atherosclerotic injury beyond LDLC. Our aim was to evaluate metabolic and innate immunity profiles in FH subjects with or without subclinical atherosclerosis. Methods: In this cross-sectional observational study, we evaluated 211 genetically confirmed FH subjects on LDLC target and without cardiovascular diseases. Biochemical analyses, LDL-C burden (LCB) calculation and vascular profile evaluation were obtained from all subjects. Study population was divided into two groups according to subclinical atherosclerosis: the subclinical atherosclerosis (SA) group and non-subclinical atherosclerosis (NSA) group. Results: SA group had higher LDL-C at diagnosis (288.35 f 24.52 vs 267.92 f 23.86, p < 0.05) and LCB (13,465.84 f 3617.46 vs 10,872.63 f 3594.7, p