Autor según el artículo: Guarro, J. Watkins, JP. Zhang, S. Lawhon, SD. Fothergill, AW. Cano, J. Sutton, DA. Paredes, K.

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Katihuska Paredes, Deanna A. Sutton, Josep Cano, Annette W. Fothergill, Sara D. Lawhon, Sean Zhang, Jeffrey P. Watkins, Josep Guarro

Resumen: Candida rugosa is a poorly known fungal species occasionally involved in human infections. A molecular analysis of the sequences of the D1/D2 domains and the internal transcribed spacer (ITS) region of the ribosomal genes of 24 clinical isolates phenotypically identi?ed as C. rugosa demonstrated that only 10 (41.6%) isolates belonged to that species. The other isolates were identi?ed as Candida pararugosa (41.6%) and Candida pseudorugosa (8.3%). The remaining two isolates, from human and equine infections, respectively, were clearly different from the others and represent a new species proposed here as Candida neorugosa. The closest species by D1/D2 sequences was the type strain of C. rugosa, with only 92.3% similarity. C. neorugosa can also be differentiated from all other species of the C. rugosa complex by phenotypic features. The eight antifungal drugs tested showed high in vitro activity against the 24 isolates included in the study.

Acceso a la licencia de uso: thttps://creativecommons.org/licenses/by/3.0/es/

Identificador del autor: https://orcid.org/0000-0002-7839-7568

Página final: 2403

Volumen de revista: 50

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: http://jcm.asm.org/content/50/7/2397

DOI del artículo: https://doi.org/10.1128/JCM.00688-12

Entidad: Universitat Rovira i Virgili.

Año de publicación de la revista: 2012

Página inicial: 2397