Articles producció científica> Medicina i Cirurgia

Serum Levels of TWEAK and Scavenger Receptor CD163 in Type 1 Diabetes Mellitus: Relationship with Cardiovascular Risk Factors. A Case-control Study.

  • Datos identificativos

    Identificador: PC:184
    Handle: https://hdl.handle.net/20.500.11797/PC184
    Autores:
    Chacón, MR.Vendrell, J.Subias, D.Maymó-Masip, E.González-Clemente, JM.Llauradó, G.
    Resumen:
    10.1371/journal.pone.0043919

  • Otros:

    Autor según el artículo: Chacón, MR. Vendrell, J. Subias, D. Maymó-Masip, E. González-Clemente, JM. Llauradó, G.
    Departamento: Bioquímica i Biotecnologia Medicina i Cirurgia
    Autor/es de la URV: Gemma Llaurado´, Jose´-Miguel Gonza´lez-Clemente, Elsa Maymo´-Masip, David Subı´as , Joan Vendrell, Matilde R. Chaco´
    Resumen: Objective: To test the usefulness of serum concentrations of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and soluble scavenger receptor CD163 (sCD163) as markers of subtle inflammation in patients with type 1 diabetes mellitus (T1DM) without clinical cardiovascular (CV) disease and to evaluate their relationship with arterial stiffness (AS). Methods: Sixty-eight patients with T1DM and 68 age and sex-matched, healthy subjects were evaluated. Anthropometrical variables and CV risk factors were recorded. Serum concentrations of sTWEAK and sCD163 were measured. AS was assessed by aortic pulse wave velocity (aPWV). All statistical analyses were stratified by gender. Results: T1DM patients showed lower serum concentrations of sTWEAK (Men: 1636.5 (1146.3–3754.8) pg/mL vs. 765.9 (650.4–1097.1) pg/mL; p,0.001. Women: 1401.0 (788.0–2422.2) pg/mL vs. 830.1 (562.6–1175.9) pg/mL; p = 0.011) compared with their respective controls. Additionally, T1DM men had higher serum concentrations of sCD163 (285.0 (247.7–357.1) ng/ mL vs. 224.8 (193.3–296.5) ng/mL; p = 0.012) compared with their respective controls. sTWEAK correlated negatively with aPWV in men (r = 20.443; p,0.001). However, this association disappeared after adjusting for potential confounders. In men, the best multiple linear regression model showed that the independent predictors of sTWEAK were T1DM and WHR (R2 = 0.640; p,0.001). In women, T1DM and SBP were the independent predictors for sTWEAK (R2 = 0.231; p = 0.001). Conclusion: sTWEAK is decreased in T1DM patients compared with age and sex-matched healthy subjects after adjusting for classic CV risk factors, although sTWEAK levels may be partially influenced by some of them. Additionally, T1DM men have higher serum concentrations of sCD163. These results point out an association between the inflammatory system and CV risk in T1DM.
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1932-6203
    Volumen de revista: 7
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427173/
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1371/journal.pone.0043919
    Entidad: Universitat Rovira i Virgili.
    Año de publicación de la revista: 2012