Autor según el artículo: Borrull, F. ; Baciu, T. ; Aguilar, M. C. ; Callul, M.
Departamento: Química Analítica i Química Orgànica
Autor/es de la URV: BORRULL BALLARÍN, FRANCESC; Baciu, T. ; AGUILAR ANGUERA, MARIA DEL CARMEN; CALULL BLANCH, MARTA
Palabras clave: chiral CE Cyclodextrin segmental hair analysis
Resumen: A suitable method has been developed and validated for simultaneously determining cocaine and its major metabolite, benzoylecgonine, 6-acetylmorphine, codeine, morphine and the methadone enantiomers in human hair samples by the in-line coupling between SPE and CyD-assisted CE with a previous sample pretreatment procedure based on pressurized liquid extraction. Optimal separation was achieved on a fused silica-capillary of 50 μm i.d. and 80 cm total length using 11 mM α-CyD in an aqueous solution of 80 mM sodium phosphate at pH 2.5 as the separation medium and an applied voltage of 30 kV. The SPE-CE device consisted of a short length of capillary packed with Oasis HLB sorbent, which was inserted near to the inlet end of the CE capillary. Several parameters affecting the in-line preconcentration were evaluated. The LOQs reached for hair samples were in the range of 0.3–2.5 ng/mg with satisfactory analytical precision in both intraday and day-to-day experiments (RSDs <13%). Relative recoveries greater than 80% were obtained. The method has successfully been applied to the determination of these drugs of abuse in segmented hair from drug abusers who were undergoing methadone maintenance treatment. The results were consistent with the patients' statements, indicating that the method established herein can be used for verifying a history of drug abuse.
Grupo de investigación: Grup de Cromatografia. Aplicacions Mediambientals
Áreas temáticas: Química Química Chemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0731-7085
Identificador del autor: 0000-0003-2718-9336; ; 0000-0002-5913-2599; 0000-0002-5258-1949
Fecha de alta del registro: 2018-03-06
Página final: 428
Volumen de revista: 131
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0731708516306057
Programa de financiación: plan; CTQ2014-52617
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.jpba.2016.09.017
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: 420
Tipo de publicación: Article Artículo Article
Repositori URV