Autor según el artículo: Guinovart, T.; Herández-Alonso, D.; Adriaenssens, L.; Blondeau, P.; Rius, F.X.; Ballester, P.; Andrade, F.J.

Departamento: Química Analítica i Química Orgànica

Autor/es de la URV: GUINOVART PAVON, TOMAS DE AQUINO; Herández-Alonso, D.; Adriaenssens, L.; BLONDEAU , PASCAL JEAN CLAUDE LEON; RIUS FERRÚS, FRANCISCO JAVIER; Ballester, P.; ANDRADE , FRANCISCO JAVIER

Resumen: An ion-selective electrode for the highly sensitive and selective determination of creatinine in urine is presented. The enhanced recognition of creatininium cations is achieved through the use of a newly synthesized calix[4]pyrrole-based molecule, which is incorporated as an ionophore into a suitable polymeric membrane. The corresponding complex formation constants with creatininium, potassium and sodium are calculated in the polymeric membrane and confirms the strong interactions between the ionophore and the target. With this approach, the potentiometric sensor presents excellent analytical parameters with good selectivity against major components of biological fluids. Furthermore, the pH control as well as the suitable dilution factor demonstrate to be mandatory for the challenging detection in real sample. The analytical performance of the sensor is indeed tested by measuring creatinine in urine samples (N=50). The results obtained are validated against the standard colorimetric technique (Jaffé’s reaction), showing that the determination can be performed in an accurate way with minimal sample manipulation. Because of the physiological relevance of the determination of creatinine and the simplicity of the approach presented, this sensor has the potential to become a powerful tool in clinical settings as well as in point of care applications.

Grupo de investigación: Grup de Quimiometria, Qualimetria i Nanosensors

Áreas temáticas: Química Química Chemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0956-5663

Identificador del autor: 0000-0002-1482-9704; 0000-0001-8673-0247; 0000-0002-8525-0580; 0000-0003-1331-5055; 0000-0003-4830-1366; 0000-0001-8377-6610; 0000-0003-1199-2837

Fecha de alta del registro: 2018-04-30

Página final: 592

Volumen de revista: 87

Versión del articulo depositado: info:eu-repo/semantics/submittedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0956566316307825

DOI del artículo: 10.1016/j.bios.2016.08.025

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Página inicial: 587

Tipo de publicación: Article Artículo Article