Articles producció científica> Química Analítica i Química Orgànica

Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry

  • Datos identificativos

    Identificador: PC:749
    Handle: https://hdl.handle.net/20.500.11797/PC749
    Autores:
    Fontanals, N.Miralles, N.Abdullah, N.Davies, A.Gilart, N.Cormack, P.A.G.
    Resumen:
    10.1016/j.chroma.2014.03.068

  • Otros:

    Autor según el artículo: Fontanals, N. Miralles, N. Abdullah, N. Davies, A. Gilart, N. Cormack, P.A.G.
    Departamento: Química Analítica i Química Orgànica
    Resumen: This paper presents eight distinct strong cation-exchange resins, all of which were derived from precursor resins that had been synthesised using either precipitation polymerisation or non-aqueous dispersion polymerisation. The precursor resins were transformed into the corresponding strong cation-exchange resins by hypercrosslinking followed by polymer analogous reactions, to yield materials with high specific surface areas and strong cation-exchange character. These novel resins were then evaluated as strong cation-exchange (SCX) sorbents in the solid-phase extraction (SPE) of a group of drugs from aqueous samples. Following preliminary experiments, the two best-performing resins were then evaluated in solid-phase extraction¿liquid chromatography¿tandem mass spectrometry (SPE/LC¿MS/MS) to determine a group of drugs from sewage samples. In general, use of these sorbents led to excellent recovery values (75¿100%) for most of the target drugs and negligible matrix effects (ME) (<20% ion suppression/enhancement of the analyte signal), when 50 mL and 25 mL of effluent and influent sewage water samples, respectively, were percolated through the resins. Finally, a validated method based on SPE/LC¿MS/MS was used to quantify the target drugs present in different sewage samples.
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0021-9673
    Página final: 62
    Volumen de revista: 1343
    Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
    Enlace a la fuente original: http://www.sciencedirect.com/science/article/pii/S0021967314005202#
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1016/j.chroma.2014.03.068
    Entidad: Universitat Rovira i Virgili.
    Año de publicación de la revista: 2014
    Página inicial: 55