Autor según el artículo: Hernández-Alonso P., Salas-Salvadó J., Ruiz-Canela M., Corella D., Estruch R., Fitó M., Arós F., Gómez-Gracia E., Fiol M., Lapetra J., Basora J., Serra-Majem L., Muñoz M.Á., Buil-Cosiales P., Saiz C., Bulló M.

Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia

Autor/es de la URV: Basora Gallisa, Josep / Bulló Bonet, Mònica / Salas Salvadó, Jorge

Palabras clave: Risk Protein Death Cardiovascular Body weight protein death cardiovascular body weight

Resumen: High dietary protein diets are widely used to manage overweight and obesity. However, there is a lack of consensus about their long-term efficacy and safety. Therefore, the aim of this study was to assess the effect of long-term high-protein consumption on body weight changes and death outcomes in subjects at high cardiovascular risk.A secondary analysis of the PREDIMED trial was conducted. Dietary protein was assessed using a food-frequency questionnaire during the follow-up. Cox proportional hazard models were used to estimate the multivariate-adjusted hazard ratio (HR) and 95% confidence intervals (95%CI) for protein intake in relation to the risk of body weight and waist circumference changes, cardiovascular disease, cardiovascular death, cancer death and total death.Higher total protein intake, expressed as percentage of energy, was significantly associated with a greater risk of weight gain when protein replaced carbohydrates (HR: 1.90; 95%CI: 1.05, 3.46) but not when replaced fat (HR: 1.69; 95%CI: 0.94, 3.03). However, no association was found between protein intake and waist circumference. Contrary, higher total protein intake was associated with a greater risk of all-cause death in both carbohydrate and fat substitution models (HR: 1.59; 95%CI: 1.08, 2.35; and HR: 1.66; 95%CI: 1.13, 2.43, respectively). A higher consumption of animal protein was associated with an increased risk of fatal and non-fatal outcomes when protein substituted carbohydrates or fat.Higher dietary protein intake is associated with long-term increased risk of body weight gain and overall death in a Mediterranean population at high cardiovascular risk.Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 02615614

Direcció de correo del autor: josep.basora@urv.cat jordi.salas@urv.cat josep.basora@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.clinicalnutritionjournal.com/article/S0261-5614(15)00091-6/fulltext#%20

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Clinical Nutrition. 35 (2): 496-506

Referencia de l'ítem segons les normes APA: Hernández-Alonso P., Salas-Salvadó J., Ruiz-Canela M., Corella D., Estruch R., Fitó M., Arós F., Gómez-Gracia E., Fiol M., Lapetra J., Basora J., Serr (2016). High dietary protein intake is associated with an increased body weight and total death risk. Clinical Nutrition, 35(2), 496-506. DOI: 10.1016/j.clnu.2015.03.016

DOI del artículo: 10.1016/j.clnu.2015.03.016

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Tipo de publicación: Journal Publications