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Serum metabolites in non-alcoholic fatty-liver disease development or reversion; A targeted metabolomic approach within the PREDIMED trial

  • Datos identificativos

    Identificador: imarina:3055993
    Autores:
    Papandreou, ChristopherBullo, MonicaJose Tinahones, FranciscoAngel Martinez-Gonzalez, MiguelCorella, DoloresFragkiadakis, Georgios ALopez-Miranda, JoseEstruch, RamonFito, MontserratSalas-Salvado, Jordi
    Resumen:
    Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in metabolites indicate predisposition to NAFLD development and to assess the effects of NAFLD reversion on metabolite profiles.A targeted liquid-chromatography tandem mass-spectrometry metabolic profiling (n = 453 metabolites) approach was applied, using serum from 45 subjects of the PREDIMED study, at baseline and after a median 3.8-year follow-up. NAFLD was determined using the hepatic steatosis index; with three groups classified and studied: Group 1, not characterized as NAFLD cases during the follow-up (n = 15); Group 2, characterized as NAFLD during the follow-up (n = 15); Group 3, characterized as NAFLD-reversion during the follow-up (n = 15).At baseline, significantly lower storage and transport lipids (triacylglycerols and cholesteryl esters), several monoetherglycerophosphocholines, acylglycerophosphocholines, ceramides and ceramide to sphingomyelin ratio (P < 0.05), were found; whereas a higher L-cystine to L-glutamate ratio (P < 0.05) was observed, in group 2 as compared to group 1.P-ether acylglycerophosphocholines, ceramides and sphingolipids were significantly different betweengroup 3 and group 1 (P < 0.05). Higher 16:1n-7 to 16:0, and 18:0 to16:0 ratio (P < 0.05), while lower 18:1n-9 to 18:0, 16:0 to 18:2n-6, and 18:3n-6 to 18:2n-6 ratio (P < 0.05) were observed in the final, compared to baseline values, in groups 2 and 3.The rearrangement of lipid biosynthesis and serum transport may indicate predisposition to NAFLD development. Despite an expected reduction of hepatic lipotoxicity and improved hepatic function in the participants of the study charact
  • Otros:

    Autor según el artículo: Papandreou, Christopher; Bullo, Monica; Jose Tinahones, Francisco; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Fragkiadakis, Georgios A; Lopez-Miranda, Jose; Estruch, Ramon; Fito, Montserrat; Salas-Salvado, Jordi
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Palabras clave: Non-alcoholic fatty liver disease Metabolomics Hepatic lipotoxicity Fatty acid metabolism metabolomics hepatic lipotoxicity fatty acid metabolism
    Resumen: Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in metabolites indicate predisposition to NAFLD development and to assess the effects of NAFLD reversion on metabolite profiles.A targeted liquid-chromatography tandem mass-spectrometry metabolic profiling (n = 453 metabolites) approach was applied, using serum from 45 subjects of the PREDIMED study, at baseline and after a median 3.8-year follow-up. NAFLD was determined using the hepatic steatosis index; with three groups classified and studied: Group 1, not characterized as NAFLD cases during the follow-up (n = 15); Group 2, characterized as NAFLD during the follow-up (n = 15); Group 3, characterized as NAFLD-reversion during the follow-up (n = 15).At baseline, significantly lower storage and transport lipids (triacylglycerols and cholesteryl esters), several monoetherglycerophosphocholines, acylglycerophosphocholines, ceramides and ceramide to sphingomyelin ratio (P < 0.05), were found; whereas a higher L-cystine to L-glutamate ratio (P < 0.05) was observed, in group 2 as compared to group 1.P-ether acylglycerophosphocholines, ceramides and sphingolipids were significantly different betweengroup 3 and group 1 (P < 0.05). Higher 16:1n-7 to 16:0, and 18:0 to16:0 ratio (P < 0.05), while lower 18:1n-9 to 18:0, 16:0 to 18:2n-6, and 18:3n-6 to 18:2n-6 ratio (P < 0.05) were observed in the final, compared to baseline values, in groups 2 and 3.The rearrangement of lipid biosynthesis and serum transport may indicate predisposition to NAFLD development. Despite an expected reduction of hepatic lipotoxicity and improved hepatic function in the participants of the study characterized as NAFLD-reversing, the side effects of NAFLD in serum metabolic profiles remained present.The trial is registered at ISRCTN35739639. Registration date: 5th October 2005.
    Áreas temáticas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iv Endocrinology, diabetes and metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 17437075
    Direcció de correo del autor: monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador del autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0213-3
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nutrition & Metabolism. 14 (1): 58-
    Referencia de l'ítem segons les normes APA: Papandreou, Christopher; Bullo, Monica; Jose Tinahones, Francisco; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Fragkiadakis, Georgios A; Lopez- (2017). Serum metabolites in non-alcoholic fatty-liver disease development or reversion; A targeted metabolomic approach within the PREDIMED trial. Nutrition & Metabolism, 14(1), 58-. DOI: 10.1186/s12986-017-0213-3
    DOI del artículo: 10.1186/s12986-017-0213-3
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Non-alcoholic fatty liver disease
    Metabolomics
    Hepatic lipotoxicity
    Fatty acid metabolism
    metabolomics
    hepatic lipotoxicity
    fatty acid metabolism
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Engenharias iv
    Endocrinology, diabetes and metabolism
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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