Autor según el artículo: Camps J, Joven J.
Departamento: Medicina i Cirurgia
Autor/es de la URV: Camps Andreu, Jorge / Joven Maried, Jorge
Palabras clave: Risk factors Oxidation Obesity Mitochondrial dysfunction Metabolism Metabolic profiling Inflammation Cytokines Biomarkers oxidation obesity mitochondrial dysfunction metabolism metabolic profiling inflammation cytokines biomarkers
Resumen: The incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing. Despite this is apparently associated with the growing increase in obesity, insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fat in the liver. Conversely, NAFLD is a predictor of other metabolic risks. NAFLD is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and end-stage liver disease. Consequently, the search for alternative molecular mechanisms with therapeutic implications in NAFLD and associated disorders deserves a careful consideration. Mitochondria are possible targets as these organelles generate energy from nutrient oxidation. Some findings, generated in patients with extreme obesity and in murine models, support the notion that NAFLD could be a mitochondrial disease. This is plausible because mitochondrial dysfunction affects the accumulation of lipids in hepatocytes and promotes lipid peroxidation, the production of reactive oxygen species, the release of cytokines causing inflammation and cell death. Here we discuss basic research and mechanistic studies targeting the role of chemokine ligand 2 in liver inflammation and that of the paraoxonases in the oxidative stress. Their combination and association with mitochondrial dysfunction may uncover mechanisms underlying the progression of NAFLD and may help to identify novel therapeutic targets.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Planejamento urbano e regional / demografia Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Gastroenterology & hepatology Gastroenterology Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.wjgnet.com/1007-9327/full/v21/i10/2875.htm
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: World Journal Of Gastroenterology. 21 (10): 2875-2882
Referencia de l'ítem segons les normes APA: Camps J, Joven J. (2015). Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors. World Journal Of Gastroenterology, 21(10), 2875-2882. DOI: 10.3748/wjg.v21.i10.2875
DOI del artículo: 10.3748/wjg.v21.i10.2875
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2015
Tipo de publicación: Journal Publications