Articles producció científica> Medicina i Cirurgia

A preliminary study of paraoxonase-1 in infected patients with an indwelling central venous catheter

  • Datos identificativos

    Identificador: imarina:3662001
    Autores:
    Iftimie, SGarcía-Heredia, APujol, IBallester, FFort-Gallifa, ISimó, JMJoven, JCastro, ACamps, J
    Resumen:
    Objectives: Identification of biochemical markers to diagnose bloodstream infections in patients with a central venous catheter (CVC) inserted is an active research pursuit. Paraoxonase-1 (PON1) is an enzyme participating in the innate immune system protecting against toxic substances and infectious agents. We investigated the relationships between serum PON1 alterations and the characteristics of infection in a group of patients with a CVC implant. Methods: Patients (n = 114) who had had an inserted CVC removed because of infection or because the usefulness was at an end, and 407 healthy volunteers were recruited. In all participants we measured serum PON1 lactonase and paraoxonase activities, PON1 concentration and genetic polymorphisms, together with levels of the chemokine (C-C motif) ligand 2 (CCL2), procalcitonin and C-reactive protein (CRP). Results: Patients with an acute concomitant infection (ACI) had higher CCL2, CRP and procalcitonin concentrations than the control group, together with lower paraoxonase and lactonase activities and specific activities. The areas under the curve of the receiver operating characteristic plots for paraoxonase and lactonase specific activities in the discrimination between patients with or without and ACI were 0.81 (0.73-0.89) and 0.81 (0.71-0.89), respectively, indicating the high diagnostic accuracy of these parameters. Conclusion: This preliminary study suggests that the measurement of PON1 may be useful as a tool for the diagnosis of ACI in patients with an indwelling CVC.
  • Otros:

    Autor según el artículo: Iftimie, S; García-Heredia, A; Pujol, I; Ballester, F; Fort-Gallifa, I; Simó, JM; Joven, J; Castro, A; Camps, J
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Ballester Bastardie, Frederic / Camps Andreu, Jorge / Castro Salomó, Antoni / Iftimie Iftimie, Simona Mihaela / Joven Maried, Jorge / Pujol Bajador, Isabel
    Palabras clave: Paraoxonase-1 Infection Catheters Biomarkers infection catheters biomarkers
    Resumen: Objectives: Identification of biochemical markers to diagnose bloodstream infections in patients with a central venous catheter (CVC) inserted is an active research pursuit. Paraoxonase-1 (PON1) is an enzyme participating in the innate immune system protecting against toxic substances and infectious agents. We investigated the relationships between serum PON1 alterations and the characteristics of infection in a group of patients with a CVC implant. Methods: Patients (n = 114) who had had an inserted CVC removed because of infection or because the usefulness was at an end, and 407 healthy volunteers were recruited. In all participants we measured serum PON1 lactonase and paraoxonase activities, PON1 concentration and genetic polymorphisms, together with levels of the chemokine (C-C motif) ligand 2 (CCL2), procalcitonin and C-reactive protein (CRP). Results: Patients with an acute concomitant infection (ACI) had higher CCL2, CRP and procalcitonin concentrations than the control group, together with lower paraoxonase and lactonase activities and specific activities. The areas under the curve of the receiver operating characteristic plots for paraoxonase and lactonase specific activities in the discrimination between patients with or without and ACI were 0.81 (0.73-0.89) and 0.81 (0.71-0.89), respectively, indicating the high diagnostic accuracy of these parameters. Conclusion: This preliminary study suggests that the measurement of PON1 may be useful as a tool for the diagnosis of ACI in patients with an indwelling CVC.
    Áreas temáticas: Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Medical laboratory technology Interdisciplinar General medicine Farmacia Ensino Educação física Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biochemistry & molecular biology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00099120
    Direcció de correo del autor: simonamihaela.iftime@urv.cat jorge.camps@urv.cat jorge.joven@urv.cat antoni.castro@urv.cat isabel.pujol@urv.cat frederic.ballester@estudiants.urv.cat
    Identificador del autor: 0000-0003-0714-8414 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-5441-6333
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://pubmed.ncbi.nlm.nih.gov/26562028/
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Clinical Biochemistry. 49 (6): 449-457
    Referencia de l'ítem segons les normes APA: Iftimie, S; García-Heredia, A; Pujol, I; Ballester, F; Fort-Gallifa, I; Simó, JM; Joven, J; Castro, A; Camps, J (2016). A preliminary study of paraoxonase-1 in infected patients with an indwelling central venous catheter. Clinical Biochemistry, 49(6), 449-457. DOI: 10.1016/j.clinbiochem.2015.11.006
    DOI del artículo: 10.1016/j.clinbiochem.2015.11.006
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Clinical Biochemistry,Medical Laboratory Technology,Medicine (Miscellaneous)
    Paraoxonase-1
    Infection
    Catheters
    Biomarkers
    infection
    catheters
    biomarkers
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Medical laboratory technology
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Educação física
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
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