Autor según el artículo: Yu E; Papandreou C; Ruiz-Canela M; Guasch-Ferre M; Clish CB; Dennis C; Liang L; Corella D; Fitó M; Razquin C; Lapetra J; Estruch R; Ros E; Cofán M; Arós F; Toledo E; Serra-Majem L; Sorlí JV; Hu FB; Martinez-Gonzalez MA; Salas-Salvado J

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Salas Salvadó, Jorge

Palabras clave: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag

Resumen: © 2018 American Association for Clinical Chemistry. BACKGROUND: Metabolites of the tryptophan– kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case– cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). METHODS: Plasma metabolite concentrations were quantified via LC-MS for n 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. RESULTS: Baseline tryptophan was associated with higher risk of incident T2D (hazard ratio 1.29; 95% CI, 1.04 –1.61 per SD). Positive changes in quinolinic acid from baseline to 1 year were associated with a higher risk of T2D (hazard ratio 1.39; 95% CI, 1.09 –1.77 per SD). Baseline tryptophan and kynurenic acid were directly associated with changes in homeostatic model assessment for insulin resistance (HOMA-IR) from baseline to 1 year. Concurrent changes in kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, and kynurenine/tryptophan ratio were associated with baseline-to-1-year changes in HOMA-IR. CONCLUSIONS: Baseline tryptophan and 1-year increases in quinolinic acid were positively associated with incident T2D. Baseline and 1-year changes in tryptophan metabolites predicted changes in HOMA-IR. Tryptophan levels may initially increase and then deplete as diabetes progresses in severity.

Áreas temáticas: Odontología Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Medical laboratory technology General medicine Farmacia Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical)

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00099147

Direcció de correo del autor: jordi.salas@urv.cat

Identificador del autor: 0000-0003-2700-7459

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://academic.oup.com/clinchem/article/64/8/1211/5608820

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Clinical Chemistry. 64 (8): 1211-1220

Referencia de l'ítem segons les normes APA: Yu E; Papandreou C; Ruiz-Canela M; Guasch-Ferre M; Clish CB; Dennis C; Liang L; Corella D; Fitó M; Razquin C; Lapetra J; Estruch R; Ros E; Cofán M; Ar (2018). Association of tryptophan metabolites with incident type 2 diabetes in the PREDIMED trial: A case–cohort study. Clinical Chemistry, 64(8), 1211-1220. DOI: 10.1373/clinchem.2018.288720

DOI del artículo: 10.1373/clinchem.2018.288720

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications