Autor según el artículo: Pallejà A, Reverter T, Garcia-Vallvé S, Romeu A.
Departamento: Bioquímica i Biotecnologia
e-ISSN: 1471-2164
Autor/es de la URV: Garcia Vallve, Santiago / ROMEU FIGUEROLA, ANTONIO RAMÓN
Palabras clave: Translation initiation Shine-dalgarno sequence Prediction Operon Gene overlaps Expression Evolution Escherichia-coli Codon Bacteria
Resumen: Background: Although prokaryotes live in a variety of habitats and possess different metabolic and genomic complexity, they have several genomic architectural features in common. The overlapping genes are a common feature of the prokaryote genomes. The overlapping lengths tend to be short because as the overlaps become longer they have more risk of deleterious mutations. The spacers between genes tend to be short too because of the tendency to reduce the non coding DNA among prokaryotes. However they must be long enough to maintain essential regulatory signals such as the Shine-Dalgarno (SD) sequence, which is responsible of an efficient translation.
Description: PairWise Neighbours is an interactive and intuitive database used for retrieving information about the spacers and overlapping genes among bacterial and archaeal genomes. It contains 1,956,294 gene pairs from 678 fully sequenced prokaryote genomes and is freely available at the URL http://genomes.urv.cat/pwneigh. This database provides information about the overlaps and their conservation across species. Furthermore, it allows the wide analysis of the intergenic regions providing useful information such as the location and strength of the SD sequence.
Conclusion: There are experiments and bioinformatic analysis that rely on correct annotations of the initiation site. Therefore, a database that studies the overlaps and spacers among prokaryotes appears to be desirable. PairWise Neighbours database permits the reliability analysis of the overlapping structures and the study of the SD presence and location among the adjacent genes, which may help to check the annotation of the initiation sites.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Genetics & heredity Genetics Farmacia Engenharias iv Engenharias iii Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biotechnology & applied microbiology Biotechnology Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: santi.garcia-vallve@urv.cat
Identificador del autor: 0000-0002-0348-7497
Fecha de alta del registro: 2023-02-18
Volumen de revista: 10
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-281
Referencia al articulo segun fuente origial: Bmc Genomics. 10
Referencia de l'ítem segons les normes APA: Pallejà A, Reverter T, Garcia-Vallvé S, Romeu A. (2009). PairWise Neighbours database: overlaps and spacers among prokaryote genomes. Bmc Genomics, 10(), -. DOI: 10.1186/1471-2164-10-281
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1186/1471-2164-10-281
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2009
Tipo de publicación: Journal Publications