Autor según el artículo: Vasson MP; Farges MC; Goncalves-Mendes N; Talvas J; Ribalta J; Winklhofer-Roob B; Rock E; Rossary A
Departamento: Medicina i Cirurgia
Autor/es de la URV: Ribalta Vives, Josep
Palabras clave: System Senieur protocol Nk cells Mediterranean diet Mediated-immunity Immune status Europe Elderly-people Delayed-type hypersensitivity Blood mononuclear-cells Biomarkers Aging Age
Resumen: Background As the European population is getting older, there is growing need in scientific data on how to achieve healthy and successful aging. A decline in immune function with age is unanimously supported by many epidemiological and clinical observations, with a decrease in T-cell mediated function encompassing a large part of this alteration. In the EU-funded VITAGE project, the effects of aging on biomarkers of immune status are being studied in three European countries. According to strict inclusion/exclusion criteria, a cohort of 300 healthy male non-smoking 20¿75 years old volunteers were enrolled in France (n = 99), Spain (n = 100) and Austria (n = 101). In each country, the volunteers were classified as a function of age (one age group per decade). Biomarkers of immune status were determined including delayed-type hypersensitivity tests, measurement of lymphocyte surface markers, and serum determinations of interleukin-2, complement fractions and immunoglobulins. Results There were moderate differences in the biomarkers of immune status of the VITAGE study volunteers among the three European centres. The percentage of Natural Killer (NK) cells was 156% and 142% higher in Spain as compared to France and Austria, respectively (p < 0.0001), and this increase was observed at any age group above 30 years. Comparison between age-groups showed that in Spain, but not in France or Austria, older individuals had significantly a lower B lymphocyte distribution and conversely, a higher NK cell distribution. Moreover, the CD4/CD8 ratio was positively correlated with age in Austrian subjects (p < 0.0001). Conclusion Our results provide evidence of an increased NK cell distribution in the elderly, especially in the Spanish population. NK cell status may predict morbidity and mortality in the elderly, emphasizing the importance of innate as well as adaptive immunity in ensuring healthy longevity and cancer resistance, possibly in link with the Mediterranean diet.
Áreas temáticas: Saúde coletiva Odontología Nutrição Medicina ii Medicina i Interdisciplinar Immunology Geriatrics & gerontology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Aging
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: josep.ribalta@urv.cat
Identificador del autor: 0000-0002-8879-4719
Fecha de alta del registro: 2023-02-18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-10-38
Referencia al articulo segun fuente origial: Immunity & Ageing. 10 (1):
Referencia de l'ítem segons les normes APA: Vasson MP; Farges MC; Goncalves-Mendes N; Talvas J; Ribalta J; Winklhofer-Roob B; Rock E; Rossary A (2013). Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain. Immunity & Ageing, 10(1), -. DOI: 10.1186/1742-4933-10-38
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1186/1742-4933-10-38
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2013
Tipo de publicación: Journal Publications
Repositori URV