Autor según el artículo: Espinel-Ingroff A; Chakrabarti A; Chowdhary A; Cordoba S; Dannaoui E; Dufresne P; Fothergill A; Ghannoum M; Gonzalez GM; Guarro J; Kidd S; Lass-Flörl C; Meis JF; Pelaez T; Tortorano AM; Turnidge J
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Guarro Artigas, Josep
Palabras clave: Zygomycosis Vitro activity Rhizopus Mucormycosis Model Infection In-vivo activities Efficacy Aspergillus Antifungal susceptibility
Resumen: Clinical breakpoints (CBPs) have not been established for the Mucorales and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four Mucorales species. Wildtype (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 Apophysomyces variabilis, 32 Cunninghamella bertholletiae, 136 Lichtheimia corymbifera, 10 Mucor indicus, 123 M. circinelloides, 19 M. ramosissimus, 349 Rhizopus arrhizus, 146 R. microsporus, 33 Rhizomucor pusillus, and 36 Syncephalastrum racemosum isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for L. corymbifera were 1 and 2 μg/ml, those for M. circinelloides were 1 and 2 μg/ml, those for R. arrhizus were 2 and 4 μg/ml, and those for R. microsporus were 2 and 2 μg/ml, respectively; posaconazole ECVs for L. corymbifera were 1 and 2, those for M. circinelloides were 4 and 4, those for R. arrhizus were 1 and 2, and those for R. microsporus were 1 and 2, respectively; both itraconazole ECVs for R. arrhizus were 2 μg/ ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.
Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Direcció de correo del autor: josep.guarro@urv.cat
Identificador del autor: 0000-0002-7839-7568
Fecha de alta del registro: 2024-07-20
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://aac.asm.org/content/59/3/1745
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 59 (3): 1745-1750
Referencia de l'ítem segons les normes APA: Espinel-Ingroff A; Chakrabarti A; Chowdhary A; Cordoba S; Dannaoui E; Dufresne P; Fothergill A; Ghannoum M; Gonzalez GM; Guarro J; Kidd S; Lass-Flörl (2015). Multicenter evaluation of MIC distributions for epidemiologic cutoff value definition to detect amphotericin B, posaconazole, and itraconazole resistance among the most clinically relevant species of Mucorales. Antimicrobial Agents And Chemotherapy, 59(3), 1745-1750. DOI: 10.1128/AAC.04435-14
DOI del artículo: 10.1128/AAC.04435-14
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2015
Tipo de publicación: Journal Publications