Articles producció científica> Medicina i Cirurgia

Limited cross-border infections in patients newly diagnosed with HIV in Europe

  • Datos identificativos

    Identificador: imarina:5128772
    Autores:
    Frentz DWensing AMJAlbert JParaskevis DAbecasis ABHamouda OJørgensen LBKücherer CStruck DSchmit JCÅsjö BBalotta CBeshkov DCamacho RJClotet BCoughlan SDe Wit SGriskevicius AGrossman ZHorban AKolupajeva TKorn KKostrikis LGLiitsola KLinka MNielsen COtelea DParedes RPoljak MPuchhammer-Stöckl ESönnerborg AStanekova DStanojevic MVandamme AMBoucher CABVan de Vijver DAMCBalluch GVercauteren JDerdelinckx ISasse AFrentz DWensing AMJAlbert JParaskevis DAbecasis ABHamouda OJørgensen LBKücherer CStruck DSchmit JCÅsjö BBalotta CBeshkov DCamacho RJClotet BCoughlan SDe Wit SGriskevicius AGrossman ZHorban AKolupajeva TKorn KKostrikis LGLiitsola KLinka MNielsen COtelea DParedes RPoljak MPuchhammer-Stöckl ESönnerborg AStanekova DStanojevic MVandamme AMBoucher CABVan de Vijver DAMCBalluch GVercauteren JDerdelinckx ISasse AFrentz DWensing AMJAlbert JParaskevis DAbecasis ABHamouda OJørgensen LBKücherer CStruck DSchmit JCÅsjö BBalotta CBeshkov DCamacho RJ
    Resumen:
    Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe.Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045).Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.
  • Otros:

    Autor según el artículo: Frentz D; Wensing AMJ; Albert J; Paraskevis D; Abecasis AB; Hamouda O; Jørgensen LB; Kücherer C; Struck D; Schmit JC; Åsjö B; Balotta C; Beshkov D; Camacho RJ; Clotet B; Coughlan S; De Wit S; Griskevicius A; Grossman Z; Horban A; Kolupajeva T; Korn K; Kostrikis LG; Liitsola K; Linka M; Nielsen C; Otelea D; Paredes R; Poljak M; Puchhammer-Stöckl E; Sönnerborg A; Stanekova D; Stanojevic M; Vandamme AM; Boucher CAB; Van de Vijver DAMC; Balluch G; Vercauteren J; Derdelinckx I; Sasse A; Frentz D; Wensing AMJ; Albert J; Paraskevis D; Abecasis AB; Hamouda O; Jørgensen LB; Kücherer C; Struck D; Schmit JC; Åsjö B; Balotta C; Beshkov D; Camacho RJ; Clotet B; Coughlan S; De Wit S; Griskevicius A; Grossman Z; Horban A; Kolupajeva T; Korn K; Kostrikis LG; Liitsola K; Linka M; Nielsen C; Otelea D; Paredes R; Poljak M; Puchhammer-Stöckl E; Sönnerborg A; Stanekova D; Stanojevic M; Vandamme AM; Boucher CAB; Van de Vijver DAMC; Balluch G; Vercauteren J; Derdelinckx I; Sasse A; Frentz D; Wensing AMJ; Albert J; Paraskevis D; Abecasis AB; Hamouda O; Jørgensen LB; Kücherer C; Struck D; Schmit JC; Åsjö B; Balotta C; Beshkov D; Camacho RJ
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Vidal Marsal, Francisco
    Palabras clave: Transmission Switzerland Subtype b Molecular epidemiology Immunodeficiency-virus type-1 Hiv-1 Europe Emergence Drug-resistant hiv-1 Clusters
    Resumen: Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe.Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045).Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.
    Áreas temáticas: Virology Saúde coletiva Química Medicina veterinaria Medicina ii Medicina i Interdisciplinar Infectious diseases Farmacia Ciências biológicas iii Ciências biológicas i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: francesc.vidal@urv.cat
    Identificador del autor: 0000-0002-6692-6186
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-10-36
    Referencia al articulo segun fuente origial: Retrovirology. 10 (1):
    Referencia de l'ítem segons les normes APA: Frentz D; Wensing AMJ; Albert J; Paraskevis D; Abecasis AB; Hamouda O; Jørgensen LB; Kücherer C; Struck D; Schmit JC; Åsjö B; Balotta C; Beshkov D; Ca (2013). Limited cross-border infections in patients newly diagnosed with HIV in Europe. Retrovirology, 10(1), -. DOI: 10.1186/1742-4690-10-36
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1186/1742-4690-10-36
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2013
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Virology
    Transmission
    Switzerland
    Subtype b
    Molecular epidemiology
    Immunodeficiency-virus type-1
    Hiv-1
    Europe
    Emergence
    Drug-resistant hiv-1
    Clusters
    Virology
    Saúde coletiva
    Química
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ciências biológicas iii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
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