Articles producció científica> Medicina i Cirurgia

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

  • Datos identificativos

    Identificador: imarina:5130363
    Autores:
    Romero-Aroca, PedroBaget-Bernaldiz, MarcPareja-Rios, AliciaLopez-Galvez, MaribelNavarro-Gil, RaulVerges, Raquel
    Resumen:
    Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.
  • Otros:

    Autor según el artículo: Romero-Aroca, Pedro; Baget-Bernaldiz, Marc; Pareja-Rios, Alicia; Lopez-Galvez, Maribel; Navarro-Gil, Raul; Verges, Raquel;
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Romero Aroca, Pedro
    Palabras clave: Pathophysiology Diabetic macular edema
    Resumen: Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.
    Áreas temáticas: Saúde coletiva Odontología Medicine, research & experimental Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: pedro.romero@urv.cat
    Identificador del autor: 0000-0002-7061-8987
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.hindawi.com/journals/jdr/2016/2156273/
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Diabetes Research. 2016 2156273-
    Referencia de l'ítem segons les normes APA: Romero-Aroca, Pedro; Baget-Bernaldiz, Marc; Pareja-Rios, Alicia; Lopez-Galvez, Maribel; Navarro-Gil, Raul; Verges, Raquel; (2016). Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory. Journal Of Diabetes Research, 2016(), 2156273-. DOI: 10.1155/2016/2156273
    DOI del artículo: 10.1155/2016/2156273
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Endocrinology,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine, Research & Experimental
    Pathophysiology
    Diabetic macular edema
    Saúde coletiva
    Odontología
    Medicine, research & experimental
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Endocrinology
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
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