FGF-23/Vitamin D Axis in Type 1 Diabetes: The Potential Role of Mineral Metabolism in Arterial Stiffness

Autor según el artículo: Llaurado, Gemma; Megia, Ana; Cano, Albert; Gimenez-Palop, Olga; Simon, Inmaculada; Gonzalez-Sastre, Montserrat; Berlanga, Eugenio; Fernandez-Veledo, Sonia; Vendrell, Joan; Gonzalez-Clemente, Jose-Miguel

Departamento: Ciències Mèdiques Bàsiques; Medicina i Cirurgia

Autor/es de la URV: Fernandez Veledo, Sonia / Megía Colet, Ana / Simón Muela, María Inmaculada / Vendrell Ortega, Juan José

Palabras clave: Vitamin-d levels; Risk; Mortality; Maintenance hemodialysis; Fibroblast growth factor-23; Fgf23; Chronic kidney-disease; Cardiovascular-disease; Calcification; All-cause

Resumen: To investigate the usefulness of Fibroblast Growth Factor 23 (FGF-23) and vitamin D as possible biomarkers of pre-clinical atherosclerosis, assessed as arterial stiffness (AS), in a group of subjects with type 1 diabetes (T1DM) and no previous cardiovascular events.68 T1DM patients and 68 age- and sex-matched controls were evaluated for 1) age, sex, diabetes duration, physical activity, smoking, alcohol intake, BMI, blood pressure, fasting plasma glucose, HbA1c, estimated glomerular filtration rate (eGFR) and lipid profile; 2) microvascular complications; 3) blood concentrations of FGF-23 and mineral metabolism parameters (calcium, phosphate, parathyroid hormone (PTH) and 25-hydroxy-vitamin D (25(OH)D)); 4) AS, assessed as aortic pulse wave velocity (aPWV); and 5) low-grade inflammation (hsCRP, IL-6, sTNF?R1, sTNF?R2) and endothelial dysfunction (ED) markers (ICAM-1, VCAM-1, E-Selectin).Patients with T1DM had higher aPWV compared with controls (p<0.001), but they did not present differences in 25(OH)D (70.3(50.4-86.2)nmol/L vs. 70.7(59.7-83.0)nmol/L; p = 0.462) and in FGF-23 plasma concentrations (70.1(38.4-151.9)RU/mL vs. 77.6(51.8-113.9)RU/mL; p = 0.329). In T1DM patients, higher concentrations of FGF-23 were positively associated with aPWV after adjusting for eGFR and classical cardiovascular risk factors (model 1: ß = 0.202, p = 0.026), other mineral metabolism parameters (model 2: ß = 0.214, p = 0.015), microvascular complications, low-grade inflammation and ED markers (model 3: ß = 0.170, p = 0.045). Lower 25(OH)D concentrations were also associated with higher aPWV after adjusting for all the above-mentioned factors (model 3: ß = -0.241, p = 0.015).We conclude that both FGF-23 plasma concentrations (positively) and 25(OH)D serum concentrations (negatively) are associated with AS in patients with T1DM and no previous cardiovascular events.

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Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: sonia.fernandez@urv.cat; ana.megia@urv.cat; jvortega@iispv.cat

Fecha de alta del registro: 2025-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140222

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Plos One. 10 (10): e0140222-

Referencia de l'ítem segons les normes APA: Llaurado, Gemma; Megia, Ana; Cano, Albert; Gimenez-Palop, Olga; Simon, Inmaculada; Gonzalez-Sastre, Montserrat; Berlanga, Eugenio; Fernandez-Veledo, S (2015). FGF-23/Vitamin D Axis in Type 1 Diabetes: The Potential Role of Mineral Metabolism in Arterial Stiffness. Plos One, 10(10), e0140222-. DOI: 10.1371/journal.pone.0140222

DOI del artículo: 10.1371/journal.pone.0140222

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2015

Tipo de publicación: Journal Publications