Autor según el artículo: Rzehak P, Covic M, Saffery R, Reischl E, Wahl S, Grote V, Weber M, Xhonneux A, Langhendries JP, Ferre N, Closa-Monasterolo R, Escribano J, Verduci E, Riva E, Socha P, Gruszfeld D, Koletzko B
Departamento: Medicina i Cirurgia
Autor/es de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia
Palabras clave: Quantile normalization Mass index Energy-balance Element-binding protein-1 Diet-induced obesity Cord blood Cell-types Cardiovascular-disease Association Adipose-tissue
Resumen: Adiposity and obesity result from the interaction of genetic variation and environmental factors from very early in life, possibly mediated by epigenetic processes. Few Epigenome-Wide-Association-Studies have identified DNA-methylation (DNAm) signatures associated with BMI and body composition in children. Body composition by Bio-Impedance-Analysis and genome-wide DNAm in whole blood were assessed in 374 pre-school children from four European countries. Associations were tested by linear regression adjusted for sex, age, centre, education, 6 WBC-proportions according to Houseman and 30 principal components derived from control probes. Specific DNAm variants were identified to be associated with BMI (212), fat-mass (230), fat-free-mass (120), fat-mass-index (24) and fat-free-mass-index (15). Probes in genes SNED1(IRE-BP1), KLHL6, WDR51A(POC1A), CYTH4-ELFN2, CFLAR, PRDM14, SOS1, ZNF643(ZFP69B), ST6GAL1, C3orf70, CILP2, MLLT4 and ncRNA LOC101929268 remained significantly associated after Bonferroni-correction of P-values. We provide novel evidence linking DNAm with (i) altered lipid and glucose metabolism, (ii) diabetes and (iii) body size and composition in children. Both common and specific epigenetic signatures among measures were also revealed. The causal direction with phenotypic measures and stability of DNAm variants throughout the life course remains unclear and longitudinal analysis in other populations is required. These findings give support for potential epigenetic programming of body composition and obesity.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Direcció de correo del autor: ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
Identificador del autor: 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41598-017-13099-4
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Scientific Reports. 7 (1): 14349-
Referencia de l'ítem segons les normes APA: Rzehak P, Covic M, Saffery R, Reischl E, Wahl S, Grote V, Weber M, Xhonneux A, Langhendries JP, Ferre N, Closa-Monasterolo R, Escribano J, Verduci E, (2017). DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study. Scientific Reports, 7(1), 14349-. DOI: 10.1038/s41598-017-13099-4
DOI del artículo: 10.1038/s41598-017-13099-4
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV