Autor según el artículo: Cantero I., Abete I., Del Bas J., Caimari A., Arola L., Zulet M., Martinez J.

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Arola Ferrer, Luis Maria

Palabras clave: Obesity Metabolic syndrome Lysophospholipids Liver Hypocaloric diet metabolic syndrome lysophospholipids liver hypocaloric diet

Resumen: Background Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to assess the influence of weight loss on lysophospholipid (LP) metabolism and liver status in obese subjects as well as to provide new evidence regarding the interaction of LP metabolism as a key factor in the onset and management of obesity-related diseases such as liver damage. Methods Thirty-three subjects from the RESMENA (Reduction of Metabolic Syndrome in Navarra, NCT01087086) study were selected based on their Fatty Liver Index (FLI). Plasma lipid species (lysophosphatidilcholine: LPC, lysophosphatidilethanolamines: LPE and lysophosphatidylinositols: LPI specifically) were determined by LC-MS, while waist circumference (WC) and other non-invasive liver markers such as, FLI and BAAT scores as well as dietary records, anthropometrical measurements, body composition by DXA and other metabolic determinants were analyzed before and after a six-month hypocaloric nutritional intervention. Results Computed Z-scores of total LP (LPC, LPE, and LPI) were significantly decreased after 6-months of following a hypocaloric diet. Specifically, LPC14:0, LPC15:0, LPC16:1, LPC18:4, LPC20:4, showed clear relationships with weight loss. Changes in FLI score, WC and BAAT score revealed associations with general changes in LPC score. Interestingly the BAAT score was statistically associated with the LPC score after adjustment for weight loss. Conclusion The lipidomic LPC profile analysis revealed a generalized decrease in circulating lysophospholipids after weight loss. The involvement of particular LP in liver metabolism and obesity merit further attention, as some of these specific non-invasive liver markers were reduced independently of weight loss.

Áreas temáticas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iv Endocrinology, diabetes and metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17437075

Direcció de correo del autor: lluis.arola@urv.cat

Identificador del autor: 0000-0003-2767-1974

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0288-5

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrition & Metabolism. 15 (51): 51-

Referencia de l'ítem segons les normes APA: Cantero I., Abete I., Del Bas J., Caimari A., Arola L., Zulet M., Martinez J. (2018). Changes in lysophospholipids and liver status after weight loss: the RESMENA study. Nutrition & Metabolism, 15(51), 51-. DOI: 10.1186/s12986-018-0288-5

DOI del artículo: 10.1186/s12986-018-0288-5

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications