Autor según el artículo: Girona, Josefa; Amigo, Nuria; Ibarretxe, Daiana; Plana, Nuria; Rodriguez-Borjabad, Celia; Heras, Mercedes; Ferre, Raimon; Gil, Miriam; Correig, Xavier; Masana, Lluis
Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
e-ISSN: 1422-0067
Autor/es de la URV: Correig Blanchar, Francesc Xavier / FERRÉ VALLÈS, RAIMON / Girona Tell, Josefa / HERAS IBAÑEZ, MERCEDES / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia
Palabras clave: Triglycerides Remnant cholesterol Ratio Normal-weight Myocardial-infarction Mortality Middle aged Metabolic syndrome Male Lipoproteins, hdl Lipids Insulin-resistance Humans Hdl-triglyceride Hdl triglycerides Hdl particle number Hdl cholesterol H-1-nmr Fenofibrate therapy Female Diabetes-mellitus Density-lipoprotein cholesterol Cardiovascular risk Cardiovascular diseases Biomarkers Aged 1h-nmr 1 h-nmr hdl triglycerides hdl particle number hdl cholesterol 1h-nmr
Resumen: While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse marker of cardiovascular risk, the importance of HDL-triglyceride (HDL-TG) concentration is not well known. We aim to examine plasma HDL-TG concentrations, assessed by 1H-NMR, in patients with metabolic diseases and their association with classical biomarkers. In this cross-sectional study, we included 502 patients with type 2 diabetes or metabolic syndrome attending the lipid unit of our University Hospital. The presence of arteriosclerotic plaques was assessed by ultrasonography. A complete lipoprotein profile was performed by 1H-NMR (Liposcale test). HDL-TG was strongly positively correlated with total triglycerides, glycerol, and fatty liver index, while a strong negative correlation was observed with HDL-cholesterol (HDL-C) and HDL-particle number (HDL-P). HDL-TG was associated with all triglyceride-rich lipoprotein parameters and had an opposite association with HDL-C and HDL-P. It was also significantly correlated with circulating cholesterol ester transfer protein (CETP). HDL-TG concentrations were higher as metabolic syndrome components increased. HDL-TG was also higher with worsening glucose metabolism. Patients with carotid plaques also showed higher HDL-TG. In contrast to HDL-C, HDL-TG is directly associated with metabolism and arteriosclerotic vascular alterations. HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14220067
Direcció de correo del autor: luis.masana@urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat xavier.correig@urv.cat
Identificador del autor: 0000-0002-0789-4954 0000-0001-8160-3716 0000-0002-6267-8779 0000-0001-8160-3716 0000-0002-6267-8779 0000-0002-6902-3054
Fecha de alta del registro: 2024-08-10
Volumen de revista: 20
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/20/13/3151
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 20 (13): 3151-
Referencia de l'ítem segons les normes APA: Girona, Josefa; Amigo, Nuria; Ibarretxe, Daiana; Plana, Nuria; Rodriguez-Borjabad, Celia; Heras, Mercedes; Ferre, Raimon; Gil, Miriam; Correig, Xavier (2019). HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk.. International Journal Of Molecular Sciences, 20(13), 3151-. DOI: 10.3390/ijms20133151
DOI del artículo: 10.3390/ijms20133151
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications