Autor según el artículo: Angelino, Donato; Carregosa, Diogo; Domenech-Coca, Cristina; Savi, Monia; Figueira, Ines; Brindani, Nicoletta; Jang, Saebyeol; Lakshman, Sukla; Molokin, Aleksey; Urban, Joseph E., Jr.; Davis, Cindy D.; Brito, Maria Alexandra; Kim, Kwang Sik; Brighenti, Furio; Curti, Claudio; Blade, Cinta; del Bas, Josep M.; Stilli, Donatella; Solano-Aguilar, Gloria, I; dos Santos, Claudia Nunes; del Rio, Daniele; Mena, Pedro;

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: BLADÉ SEGARRA, MARIA CINTA / Del Bas Prior, José María / DOMENECH COCA, CRISTINA

Palabras clave: Valerolactone Rats Proanthocyanidin Prediction Polyphenols Permeability Neurodegenerative disease Metabolites Gut Flavan-3-ol Drug solubility Cognitive decline Cocoa Catechin Blood brain barrier proanthocyanidin polyphenols permeability neurodegenerative disease metabolites gut flavan-3-ol catechin blood brain barrier

Resumen: Phenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally rearranged by gut microbiota, yielding smaller and more polar metabolites like phenyl-gamma-valerolactones, phenylvaleric acids and their conjugates. The present work investigated the ability of F3O-derived metabolites to cross the blood-brain barrier (BBB), by linking five experimental models with increasing realism. First, an in silico study examined the physical-chemical characteristics of F3O metabolites to predict those most likely to cross the BBB. Some of these metabolites were then tested at physiological concentrations to cross the luminal and abluminal membranes of brain microvascular endothelial cells, cultured in vitro. Finally, three different in vivo studies in rats injected with pure 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone, and rats and pigs fed grapes or a F3O-rich cocoa extract, respectively, confirmed the presence of 5-(hydroxyphenyl)-gamma-valerolactone-sulfate (3',4' isomer) in the brain. This work highlighted, with different experimental models, the BBB permeability of one of the main F3O-derived metabolites. It may support the neuroprotective effects of phenolic-rich foods in the frame of the gut-brain axis.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Direcció de correo del autor: josepm.delbas@urv.cat

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/11/11/2678

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 11 (11):

Referencia de l'ítem segons les normes APA: Angelino, Donato; Carregosa, Diogo; Domenech-Coca, Cristina; Savi, Monia; Figueira, Ines; Brindani, Nicoletta; Jang, Saebyeol; Lakshman, Sukla; Moloki (2019). 5-(Hydroxyphenyl)-gamma-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models. Nutrients, 11(11), -. DOI: 10.3390/nu11112678

DOI del artículo: 10.3390/nu11112678

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Tipo de publicación: Journal Publications