Articles producció científica> Enginyeria Química

Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition

  • Datos identificativos

    Identificador: imarina:6063462
    Autores:
    Junqué EGarcia SMartínez MRovira JSchuhmacher MGrimalt J
    Resumen:
    © 2019 Elsevier Inc. The concentrations of organochlorine compounds (OCs), including pentachlorobenzene, hexachlorobenzene (HCB), hexachlorocyclohexanes (α-, β-, γ- and δ-HCH), polychlorobiphenyls (PCBs 28, 52, 101, 118, 138, 153 and 180), DDT and metabolites, were measured in maternal serum samples collected at the first trimester of pregnancy, at delivery and in umbilical cord from a cohort of mother-newborn pairs from Tarragona (Spain) (n = 50), representing general population of a Mediterranean area from Southern Europe. The observed concentrations were generally low in comparison with previous studies in other world areas. Higher OC concentrations were observed in the maternal serum collected at delivery than in the first trimester and the cord blood concentrations were lower than the maternal levels. These results show for the first time a small but statistically significant increase in maternal venous concentration of OCs between the first trimester and delivery when measured in ng/ml. HCB, β-HCH and the PCB congeners in cord blood were significantly correlated with the concentrations of these compounds in maternal venous blood and the coefficients were stronger for the samples collected at delivery which was consistent with OC transfer from mother to foetus. In the case of DDT compounds, only 4,4′-DDT showed maternal-cord blood correlation which documented the low metabolic capacity of newborns for OC transformation, e.g. DDT into DDE. Maternal age was the most significant driver of the observed maternal venous OC concentrations in both periods, older ages involving higher concentrations. Higher body mass index was only significantly correlated with higher 4,4′-DDE concentrations in maternal venous blood and cord blood. In some cases, social class and education
  • Otros:

    Autor según el artículo: Junqué E; Garcia S; Martínez M; Rovira J; Schuhmacher M; Grimalt J
    Departamento: Enginyeria Química
    Autor/es de la URV: Martínez Rodríguez, María Ángeles / Rovira Solano, Joaquim / Schuhmacher Ansuategui, Marta
    Palabras clave: Umbilical cord serum Spain Prenatal exposure Pregnancy trimester, first Pregnancy Polychlorinated biphenyls Organochlorine compounds Mother-to-foetus pollutant transfer Maternal serum Infant, newborn Hydrocarbons, chlorinated Humans Human biomonitoring Fetal blood Female Europe Environmental pollutants Age factors Adult prenatal exposure organochlorine compounds mother-to-foetus pollutant transfer maternal serum human biomonitoring
    Resumen: © 2019 Elsevier Inc. The concentrations of organochlorine compounds (OCs), including pentachlorobenzene, hexachlorobenzene (HCB), hexachlorocyclohexanes (α-, β-, γ- and δ-HCH), polychlorobiphenyls (PCBs 28, 52, 101, 118, 138, 153 and 180), DDT and metabolites, were measured in maternal serum samples collected at the first trimester of pregnancy, at delivery and in umbilical cord from a cohort of mother-newborn pairs from Tarragona (Spain) (n = 50), representing general population of a Mediterranean area from Southern Europe. The observed concentrations were generally low in comparison with previous studies in other world areas. Higher OC concentrations were observed in the maternal serum collected at delivery than in the first trimester and the cord blood concentrations were lower than the maternal levels. These results show for the first time a small but statistically significant increase in maternal venous concentration of OCs between the first trimester and delivery when measured in ng/ml. HCB, β-HCH and the PCB congeners in cord blood were significantly correlated with the concentrations of these compounds in maternal venous blood and the coefficients were stronger for the samples collected at delivery which was consistent with OC transfer from mother to foetus. In the case of DDT compounds, only 4,4′-DDT showed maternal-cord blood correlation which documented the low metabolic capacity of newborns for OC transformation, e.g. DDT into DDE. Maternal age was the most significant driver of the observed maternal venous OC concentrations in both periods, older ages involving higher concentrations. Higher body mass index was only significantly correlated with higher 4,4′-DDE concentrations in maternal venous blood and cord blood. In some cases, social class and education level were significantly correlated with OC concentrations, e.g. 4,4′-DDE in maternal venous blood from the first trimester and cord blood and PCB153 in maternal venous blood at delivery. In these cases, highest concentrations were found in the women with highest education level and most affluent social class. Comparison of the maternal OC concentrations of this cohort with those observed in 2002 in population of the same geographic area and age range shows decreases between two and ten times over this fourteen-year period.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0013-9351
    Direcció de correo del autor: mangeles.martinez@urv.cat joaquim.rovira@urv.cat marta.schuhmacher@urv.cat
    Identificador del autor: 0000-0001-8595-3772 0000-0003-4399-6138 0000-0003-4381-2490
    Fecha de alta del registro: 2024-07-27
    Volumen de revista: 182
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0013935119307911?via%3Dihub
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Environmental Research. 182 (108994): 108994-
    Referencia de l'ítem segons les normes APA: Junqué E; Garcia S; Martínez M; Rovira J; Schuhmacher M; Grimalt J (2020). Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition. Environmental Research, 182(108994), 108994-. DOI: 10.1016/j.envres.2019.108994
    DOI del artículo: 10.1016/j.envres.2019.108994
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Umbilical cord serum
    Spain
    Prenatal exposure
    Pregnancy trimester, first
    Pregnancy
    Polychlorinated biphenyls
    Organochlorine compounds
    Mother-to-foetus pollutant transfer
    Maternal serum
    Infant, newborn
    Hydrocarbons, chlorinated
    Humans
    Human biomonitoring
    Fetal blood
    Female
    Europe
    Environmental pollutants
    Age factors
    Adult
    prenatal exposure
    organochlorine compounds
    mother-to-foetus pollutant transfer
    maternal serum
    human biomonitoring
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
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