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Adipose Tissue and Serum CCDC80 in Obesity and Its Association with Related Metabolic Disease

  • Datos identificativos

    Identificador: imarina:6069240
    Autores:
    Osorio-Conles, OscarGuitart, MariaMaria Moreno-Navarrete, JoseEscote, XavierDuran, XavierManuel Fernandez-Real, JoseMaria Gomez-Foix, AnnaFernandez-Veledo, SoniaVendrell, Joan
    Resumen:
    Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link between human CCDC80 and obesity. CCDC80 protein expression was assessed in paired visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) from 10 patients (body mass index range 22.4-38.8 kg/m(2)). Circulating CCDC80 levels were quantified in serum samples from two independent cross-sectional cohorts comprising 33 lean and 15 obese (cohort 1) and 32 morbidly obese (cohort 2) male patients. Insulin sensitivity, insulin secretion and blood neutrophil count were quantified in serum samples from both cohorts. Additionally, circulating free insulin-like growth factor (IGF)-1 levels and oral glucose tolerance tests were assessed in cohort 1, whereas C-reactive protein levels and degree of atherosclerosis and hepatic steatosis were studied in cohort 2. In lean patients, total CCDC80 protein content assessed by immunoblotting was lower in VAT than in SAT. In obese patients, CCDC80 was increased in VAT (P < 0.05) but equivalent in SAT compared with lean counterparts. In cohort 1, serum CCDC80 correlated negatively with the acute insulin response to glucose and IGF-1 levels and positively with blood neutrophil count independent of BMI, but not with insulin sensitivity. In cohort 2, serum CCDC80 was positively linked to the inflammatory biomarker C-reactive protein (r = 0.46; P = 0.009), atherosclerosis (carotid intima-media thickness, r = 0.62; P < 0.001) and hepatic steatosis (analysis of variance P = 0.025). Overall, these results suggest for the first time that CCDC80 may be a component of the obesity-altered secretome in VAT and could act as an adipokine whose
  • Otros:

    Autor según el artículo: Osorio-Conles, Oscar; Guitart, Maria; Maria Moreno-Navarrete, Jose; Escote, Xavier; Duran, Xavier; Manuel Fernandez-Real, Jose; Maria Gomez-Foix, Anna; Fernandez-Veledo, Sonia; Vendrell, Joan;
    Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    Autor/es de la URV: Escote Miro, Xavier / Fernandez Veledo, Sonia / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José
    Palabras clave: Visceral adipose tissue Vendrell Serum ccdc80 Protein Osorio-conles Obesity Moreno-navarrete Metabolic disease Insulin-resistance Inflammation Guitart Gómez-foix Gene Fernández-veledo Fernandez-real Expression Escoté Duran Differentiation Cells Capacity Atherosclerosis Adipose tissue Adipokines subcutaneous adipose tissue obesity ccdc80 adipokines
    Resumen: Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link between human CCDC80 and obesity. CCDC80 protein expression was assessed in paired visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) from 10 patients (body mass index range 22.4-38.8 kg/m(2)). Circulating CCDC80 levels were quantified in serum samples from two independent cross-sectional cohorts comprising 33 lean and 15 obese (cohort 1) and 32 morbidly obese (cohort 2) male patients. Insulin sensitivity, insulin secretion and blood neutrophil count were quantified in serum samples from both cohorts. Additionally, circulating free insulin-like growth factor (IGF)-1 levels and oral glucose tolerance tests were assessed in cohort 1, whereas C-reactive protein levels and degree of atherosclerosis and hepatic steatosis were studied in cohort 2. In lean patients, total CCDC80 protein content assessed by immunoblotting was lower in VAT than in SAT. In obese patients, CCDC80 was increased in VAT (P < 0.05) but equivalent in SAT compared with lean counterparts. In cohort 1, serum CCDC80 correlated negatively with the acute insulin response to glucose and IGF-1 levels and positively with blood neutrophil count independent of BMI, but not with insulin sensitivity. In cohort 2, serum CCDC80 was positively linked to the inflammatory biomarker C-reactive protein (r = 0.46; P = 0.009), atherosclerosis (carotid intima-media thickness, r = 0.62; P < 0.001) and hepatic steatosis (analysis of variance P = 0.025). Overall, these results suggest for the first time that CCDC80 may be a component of the obesity-altered secretome in VAT and could act as an adipokine whose circulant levels are linked to glucose tolerance derangements and related to inflammation-associated chronic complications.
    Áreas temáticas: Molecular medicine Molecular biology Medicine, research & experimental Medicina iii Medicina ii Medicina i Materiais Genetics (clinical) Genetics Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cell biology Biotecnología Biochemistry & molecular biology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 10761551
    Direcció de correo del autor: xavier.escote@urv.cat sonia.fernandez@urv.cat juanjose.vendrell@urv.cat
    Identificador del autor: 0000-0003-1172-3995 0000-0003-2906-3788 0000-0002-6994-6115
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://molmed.biomedcentral.com/articles/10.2119/molmed.2017.00067
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Medicine. 23 225-234
    Referencia de l'ítem segons les normes APA: Osorio-Conles, Oscar; Guitart, Maria; Maria Moreno-Navarrete, Jose; Escote, Xavier; Duran, Xavier; Manuel Fernandez-Real, Jose; Maria Gomez-Foix, Anna (2017). Adipose Tissue and Serum CCDC80 in Obesity and Its Association with Related Metabolic Disease. Molecular Medicine, 23(), 225-234. DOI: 10.2119/molmed.2017.00067
    DOI del artículo: 10.2119/molmed.2017.00067
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Cell Biology,Genetics,Genetics (Clinical),Medicine, Research & Experimental,Molecular Biology,Molecular Medicine
    Visceral adipose tissue
    Vendrell
    Serum ccdc80
    Protein
    Osorio-conles
    Obesity
    Moreno-navarrete
    Metabolic disease
    Insulin-resistance
    Inflammation
    Guitart
    Gómez-foix
    Gene
    Fernández-veledo
    Fernandez-real
    Expression
    Escoté
    Duran
    Differentiation
    Cells
    Capacity
    Atherosclerosis
    Adipose tissue
    Adipokines
    subcutaneous adipose tissue
    obesity
    ccdc80
    adipokines
    Molecular medicine
    Molecular biology
    Medicine, research & experimental
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Genetics (clinical)
    Genetics
    Engenharias iv
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cell biology
    Biotecnología
    Biochemistry & molecular biology
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