Autor según el artículo: Peris-Sampedro F; Guardia-Escote L; Basaure P; Cabré M; Colomina MT

Departamento: Bioquímica i Biotecnologia Psicologia

Autor/es de la URV: BASAURE GARCÍA, PÍA ISABEL / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Guardia Escoté, Laia

Palabras clave: Targeted-replacement Pesticide Open-field Motivation Exposure Cholinesterase inhibitor Chlorpyrifos Apolipoprotein-e Apolipoprotein e4 Apoe genotype Anxiety-like behavior Anxiety Alzheimers-disease 3xtg-ad mice cholinesterase inhibitor chlorpyrifos apolipoprotein e4 anxiety

Resumen: © 2020 Elsevier B.V. The apolipoprotein E (APOE) ε4 allele hastens cognitive decline, but other non-cognitive behaviours, as well as underpinning interactions with the cholinergic system, have not been systematically addressed. Both C57BL/6 and humanised apoE4 female mice were transiently exposed to subclinical doses (0 or 1 mg/kg body weight) of the cholinesterase inhibitor chlorpyrifos (CPF), a widely-used pesticide, from postnatal days 10–15. At 5 months of age, we assessed the impact of APOE4 genotype, postnatal CPF exposure and APOE4 x CPF interactions on anxiety (open field and light-dark tests), stereotypes (digging test) and neophobia (sucrose preference test), as well as on high-fat diet (HFD)-seeking and consumption (scheduled-feeding paradigm). We found that control APOE4 female carriers displayed a robust anxiety-like phenotype, which was accompanied by exaggerated stereotypes and a subtle neophobic response to rewarding foods. In parallel, we observed an amplified “wanting” response for HFD in these mice, which did not entail enhanced “liking”. Notably, postnatal CPF ameliorated the anxiety-like and the heightened HFD-seeking responses in adult apoE4 female mice, while caused them to gain weight steadily compared to control peers. In turn, an early-life transient exposure to CPF fostered the over-consumption of HFD during adulthood without affecting how much this reward was “wanted” or the total caloric intake. These data reveal a role for CPF towards fostering “unhealthy” dietary choices. We conclude that the APOE4 genotype modulates non-cognitive behaviours and we provide support for an APOE4-dependent cholinergic dysfunction.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Odontología Nutrição Neurosciences Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Filosofia/teologia:subcomissão filosofia Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Behavioral sciences Behavioral neuroscience Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 01664328

Direcció de correo del autor: mariateresa.colomina@urv.cat maria.cabre@urv.cat

Identificador del autor: 0000-0002-5619-4874 0000-0003-4124-8603

Fecha de alta del registro: 2023-02-22

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0166432819316493

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Behavioural Brain Research. 384 (112552): 112552-

Referencia de l'ítem segons les normes APA: Peris-Sampedro F; Guardia-Escote L; Basaure P; Cabré M; Colomina MT (2020). Improvement of APOE4-dependent non-cognitive behavioural traits by postnatal cholinergic stimulation in female mice. Behavioural Brain Research, 384(112552), 112552-. DOI: 10.1016/j.bbr.2020.112552

DOI del artículo: 10.1016/j.bbr.2020.112552

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications