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Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study

  • Datos identificativos

    Identificador: imarina:6290530
  • Autores:

    Malo, Ana-Irene
    Rull, Anna
    Girona, Josefa
    Domingo, Pere
    Fuertes-Martin, Rocio
    Amigo, Nuria
    Rodriguez-Borjabad, Celia
    Martinez-Micaelo, Neus
    Leal, Manuel
    Peraire, Joaquim
    Correig, Xavier
    Vidal, Francesc
    Masana, Lluis
  • Otros:

    Autor según el artículo: Malo, Ana-Irene; Rull, Anna; Girona, Josefa; Domingo, Pere; Fuertes-Martin, Rocio; Amigo, Nuria; Rodriguez-Borjabad, Celia; Martinez-Micaelo, Neus; Leal, Manuel; Peraire, Joaquim; Correig, Xavier; Vidal, Francesc; Masana, Lluis
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
    Autor/es de la URV: Correig Blanchar, Francesc Xavier / Girona Tell, Josefa / Malo Cerisuelo, Ana Irene / Martínez Micaelo, Nieves Beatriz / Masana Marín, Luis / Peraire Forner, José Joaquin / Rodríguez Borjabad, Cèlia / RULL AIXA, ANNA / Vidal Marsal, Francisco
    Palabras clave: Therapy Responses Proton nuclear magnetic resonance (h-1-nmr) Proton nuclear magnetic resonance (1h-nmr) Mortality Mechanisms Inflammation Immunological responders Immune activation Hiv-1 Glycosylation Glycoprotein Disease Coagulation C-reactive protein Biomarkers
    Resumen: Plasma glycoproteins are a composite biomarker of inflammation and can be detected by 1H-NMR. The aim of this study was to prospectively appraise the clinical value of plasma glycoproteins assessed by 1H-NMR in people living with HIV (PLWH). A total of 221 patients with HIV infection were recruited and studied at baseline and at 48 and 144 weeks. Patients were distributed into two groups according to baseline CD4+ T-cell number below or above 200 cells/µL. Patients with fewer than 200 cells/µL were distributed into the responders and nonresponders according to antiretroviral therapy (ART) response at 144 weeks. Glycoprotein concentrations were determined by 1H-NMR arising from the protein bond N-acetylglucosamine and N-acetylgalactosamine signals (GlycA); and N-acetylneuraminic acid signal (GlycB) associated with the sugar-protein bond concentration and aggregation state (shapes (height/width)). Basal glycoprotein concentrations were higher in patients with < 200 CD4+ T-cell/μL (Glyc A: 1040(917.9-1199.1) vs. 950.4(845.5-1050.9), p < 0.001, and Glyc B: 521(440.3-610.3) vs. 468.6(417.9-507.0) μ mol/L, p < 0.001) being reduced by ART. The height/width (H/W) ratio was the parameter showing a better association with this clinical status. Baseline glycoproteins predict the condition of responder/nonresponder. In this study, 1H-NMR glycoproteins provide novel insights to assess inflammation status and have prognostic value in PLWH.
    Áreas temáticas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20770383
    Direcció de correo del autor: neus.martinez@urv.cat luis.masana@urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat joaquim.peraire@urv.cat anairene.malo@estudiants.urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat xavier.correig@urv.cat francesc.vidal@urv.cat
    Identificador del autor: 0000-0002-0789-4954 0000-0001-8160-3716 0000-0002-6267-8779 0000-0001-7808-5479 0000-0001-8160-3716 0000-0002-6267-8779 0000-0002-6902-3054 0000-0002-6692-6186
    Fecha de alta del registro: 2024-08-10
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2077-0383/9/5/1344/htm
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Clinical Medicine. 9 (5): 1344-
    Referencia de l'ítem segons les normes APA: Malo, Ana-Irene; Rull, Anna; Girona, Josefa; Domingo, Pere; Fuertes-Martin, Rocio; Amigo, Nuria; Rodriguez-Borjabad, Celia; Martinez-Micaelo, Neus; Le (2020). Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study. Journal Of Clinical Medicine, 9(5), 1344-. DOI: 10.3390/jcm9051344
    DOI del artículo: 10.3390/jcm9051344
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Medicine, General & Internal
    Therapy
    Responses
    Proton nuclear magnetic resonance (h-1-nmr)
    Proton nuclear magnetic resonance (1h-nmr)
    Mortality
    Mechanisms
    Inflammation
    Immunological responders
    Immune activation
    Hiv-1
    Glycosylation
    Glycoprotein
    Disease
    Coagulation
    C-reactive protein
    Biomarkers
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
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