Articles producció científica> Ciències Mèdiques Bàsiques

Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome

  • Datos identificativos

    Identificador: imarina:6387671
    Autores:
    Taltavull NMuñoz-Cortés MLluís LJové MFortuño AMolinar-Toribio ETorres JPazos MMedina INogués M
    Resumen:
    Background: Marine polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been associated with improvement in the Metabolic Syndrome (MS). The aim of this study is to evaluate how three fish-oil diets with different eicosapentaenoic acid/docosahexaenoic acid ratios (EPA/DHA ratio) affect the histology of liver, kidney, adipose tissue and aorta in a preliminary morphological study. This work uses an animal model of metabolic syndrome in comparison with healthy animals in order to provide information about the best EPA:DHA ratio to prevent or to improve metabolic syndrome symptoms. Methods. 35 Wistar rats, as a control, and 35 spontaneously hypertensive obese rats (SHROB) were fed for 13 weeks with 3 different suplemmentation of fish oil containing EPA and DHA ratios (1:1, 2:1 and 1:2, respectively). All samples were stained with haematoxylin/eosin stain, except aorta samples, which were stained also with Verhoeff and van Gieson's stain. A histological study was carried out to evaluate changes. These changes were statistically analyzed using SPSS IBM 19 software. The quantitative data were expressed by mean ± SD and were compared among groups and treatments using ANOVA with post-hoc tests for parametric data and the U-Mann-Whitney for non-parametric data. Qualitative data were expressed in frequencies, and compared with contingency tables using χ§ssup§2§esup§ statistics. Results: EPA:DHA 1:1 treatment tended to improve the density and the wrinkling of elastic layers in SHROB rats. Only Wistar rats fed with EPA:DHA 1:1 treatment did not show mast cells in adipose tissue and has less kidney atrophy. In both strains EPA:DHA 1:1 treatment improved inflammation related parameters in liver and kidney. Conclusions: EPA:DHA 1:1 treatment was
  • Otros:

    Autor según el artículo: Taltavull N; Muñoz-Cortés M; Lluís L; Jové M; Fortuño A; Molinar-Toribio E; Torres J; Pazos M; Medina I; Nogués M
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Jove Sans, María Montserrat / LLUÍS RODRÍGUEZ, LAURA / Muñoz Cortés, Mónica / Nogués Llort, Maria Rosa / Taltavull Anglada, Núria
    Palabras clave: Shrob rats Omega-3-polyunsaturated fatty acids Omega-3 pufa Metabolic syndrome Histology Fish oils Epa/dha ratio
    Resumen: Background: Marine polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been associated with improvement in the Metabolic Syndrome (MS). The aim of this study is to evaluate how three fish-oil diets with different eicosapentaenoic acid/docosahexaenoic acid ratios (EPA/DHA ratio) affect the histology of liver, kidney, adipose tissue and aorta in a preliminary morphological study. This work uses an animal model of metabolic syndrome in comparison with healthy animals in order to provide information about the best EPA:DHA ratio to prevent or to improve metabolic syndrome symptoms. Methods. 35 Wistar rats, as a control, and 35 spontaneously hypertensive obese rats (SHROB) were fed for 13 weeks with 3 different suplemmentation of fish oil containing EPA and DHA ratios (1:1, 2:1 and 1:2, respectively). All samples were stained with haematoxylin/eosin stain, except aorta samples, which were stained also with Verhoeff and van Gieson's stain. A histological study was carried out to evaluate changes. These changes were statistically analyzed using SPSS IBM 19 software. The quantitative data were expressed by mean ± SD and were compared among groups and treatments using ANOVA with post-hoc tests for parametric data and the U-Mann-Whitney for non-parametric data. Qualitative data were expressed in frequencies, and compared with contingency tables using χ§ssup§2§esup§ statistics. Results: EPA:DHA 1:1 treatment tended to improve the density and the wrinkling of elastic layers in SHROB rats. Only Wistar rats fed with EPA:DHA 1:1 treatment did not show mast cells in adipose tissue and has less kidney atrophy. In both strains EPA:DHA 1:1 treatment improved inflammation related parameters in liver and kidney. Conclusions: EPA:DHA 1:1 treatment was the most beneficial treatment since improved many histological parameters in both groups of rats. © 2014 Taltavull et al.; licensee BioMed Central Ltd.
    Áreas temáticas: Saúde coletiva Química Odontología Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Enfermagem Endocrinology, diabetes and metabolism Endocrinology Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Biochemistry (medical) Biochemistry & molecular biology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1476511X
    Direcció de correo del autor: monica.munoz@urv.cat nuria.taltavull@urv.cat montserrat.jove@urv.cat
    Identificador del autor: 0000-0002-3340-2650
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-31
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Lipids In Health And Disease. 13 (1):
    Referencia de l'ítem segons les normes APA: Taltavull N; Muñoz-Cortés M; Lluís L; Jové M; Fortuño A; Molinar-Toribio E; Torres J; Pazos M; Medina I; Nogués M (2014). Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome. Lipids In Health And Disease, 13(1), -. DOI: 10.1186/1476-511X-13-31
    DOI del artículo: 10.1186/1476-511X-13-31
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2014
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Biochemistry (Medical),Clinical Biochemistry,Endocrinology,Endocrinology, Diabetes and Metabolism,Nutrition & Dietetics
    Shrob rats
    Omega-3-polyunsaturated fatty acids
    Omega-3 pufa
    Metabolic syndrome
    Histology
    Fish oils
    Epa/dha ratio
    Saúde coletiva
    Química
    Odontología
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Ensino
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry (medical)
    Biochemistry & molecular biology
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