Autor según el artículo: Peris-Sampedro F; Reverte I; Basaure P; Cabré M; Domingo J; Colomina M
Departamento: Ciències Mèdiques Bàsiques Psicologia
Autor/es de la URV: BASAURE GARCÍA, PÍA ISABEL / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / REVERTÉ SOLER, INGRID
Palabras clave: Reaction time Motivation Mice, transgenic Mice Maze learning Insecticides Impulsivity Impulsive behavior Humans Genotype Female Chlorpyrifos Attention Apolipoproteins e Apolipoprotein e Animals 5-csrtt impulsivity chlorpyrifos attention apolipoprotein e 5-csrtt
Resumen: © 2016 Elsevier Ltd. Organophosphate pesticides - and chlorpyrifos (CPF) in particular - contribute to a wide range of neurobehavioural disorders. Most experimental research focuses on learning and memory processes, while other behaviours remain understudied. The isoforms of the human apolipoprotein E (apoE) confer different cognitive skills on their carriers, but data on this topic are still limited. The current study was performed to assess whether the APOE genotypic variability differently modulates the effects of CPF on attentional performance, inhibitory control and motivation. Human apoE targeted replacement adult female mice (apoE2, apoE3 and apoE4) were trained to stably perform the 5-choice serial reaction time task (5-CSRTT). Animals were then subjected to daily dietary CPF (3.75 mg/kg body weight) for 4 weeks. After CPF exposure, we established a 4-week CPF-free period to assess recovery. All individuals acquired the task, apoE2 mice showed enhanced learning, while apoE4 mice displayed increased premature and perseverative responding. This genotype-dependent lack of inhibitory control was reversed by CPF. Overall, the pesticide induced protracted impairments in sustained attention and motivation, and it reduced anticipatory responding. ApoE3 mice exhibited delayed attentional disruptions throughout the wash-out period. Taken together, these findings provide notable evidence on the emergence of CPF-related attentional and motivational deficits.
Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Direcció de correo del autor: maria.cabre@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat
Identificador del autor: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0278691516300795?via%3Dihub
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 92 224-235
Referencia de l'ítem segons les normes APA: Peris-Sampedro F; Reverte I; Basaure P; Cabré M; Domingo J; Colomina M (2016). Apolipoprotein E (APOE) genotype and the pesticide chlorpyrifos modulate attention, motivation and impulsivity in female mice in the 5-choice serial reaction time task. Food And Chemical Toxicology, 92(), 224-235. DOI: 10.1016/j.fct.2016.03.029
DOI del artículo: 10.1016/j.fct.2016.03.029
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Tipo de publicación: Journal Publications