Autor según el artículo: Basaure P; Peris-Sampedro F; Cabré M; Reverte I; Colomina M
Departamento: Psicologia Bioquímica i Biotecnologia
Autor/es de la URV: BASAURE GARCÍA, PÍA ISABEL / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / REVERTÉ SOLER, INGRID
Palabras clave: acetylcholinesterase isoform chlorpyrifos cholinesterase inhibitor learning memory Acetylcholinesterase Acetylcholinesterase isoform Animals Body weight Brain Chlorpyrifos Cholinesterase inhibitor Cholinesterase inhibitors Dose-response relationship, drug Learning Male Maze learning Memory Mice Rivastigmine
Resumen: © 2016 Elsevier B.V. Cholinesterases (ChE) are common targets of organophosphate (OP) pesticides and play a critical role in the pathology of some dementias. While chlorpyrifos (CPF) remains one of the most commonly used OPs in the world, numerous investigations have reported its neurotoxic potential and highlighted behavioral disturbances upon its administration. Rivastigmine currently serves to treat Alzheimer's disease, but it may induce cholinergic overstimulation in non-demented individuals. The present investigation aimed to compare the acute and delayed effects caused by both ChE inhibitors in adult C57BL/6 male mice. The animals were daily fed either a standard, a CPF- (5 mg/kg body weight) or a rivastigmine-supplemented diet (1 or 2 mg/kg body weight) for 8 weeks. After the treatment, we established an 8-week washout period to assess recovery. ChE enzyme activity, biomarkers, physical effects, and behavioral alterations were evaluated at different time points during the exposure and after the washout period. Both rivastigmine doses induced a time-dependent weight increase. CPF and rivastigmine inhibited brain acetylcholinesterase following an isoform-specific pattern. As for behavioral assessment, CPF negatively modulated learning strategies and impaired memory in a Barnes maze task at the end of the exposure. On the other hand, the low dose of rivastigmine improved memory recall at the end of the washout period in a Morris water maze. Indeed, our results endorse the positive effects of low doses of rivastigmine following a drug-free period in young mice. Therefore, doses and periodicity of treatment to improve cognition in elderly people upon rivastigmine administration should be revised.
Áreas temáticas: Administração pública e de empresas, ciências contábeis e turismo Behavioral neuroscience Behavioral sciences Biodiversidade Biotecnología Ciência de alimentos Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Ciencias sociales Educação física Enfermagem Engenharias ii Engenharias iv Ensino Farmacia Filosofia/teologia:subcomissão filosofia Interdisciplinar Matemática / probabilidade e estatística Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Neurosciences Nutrição Odontología Psicología Psychology Química Saúde coletiva Zootecnia / recursos pesqueiros
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: maria.cabre@urv.cat mariateresa.colomina@urv.cat
ISSN: 01664328
Identificador del autor: 0000-0003-4124-8603 0000-0002-5619-4874
Fecha de alta del registro: 2024-06-28
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0166432816307938?via%3Dihub
Referencia al articulo segun fuente origial: Behavioural Brain Research. 318 1-11
Referencia de l'ítem segons les normes APA: Basaure P; Peris-Sampedro F; Cabré M; Reverte I; Colomina M (2017). Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: The case of chlorpyrifos and rivastigmine. Behavioural Brain Research, 318(), 1-11. DOI: 10.1016/j.bbr.2016.10.014
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.bbr.2016.10.014
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV