Autor según el artículo: Valverde C; Lligadas G; Ronda JC; Galià M; Cádiz V
Departamento: Química Analítica i Química Orgànica
Autor/es de la URV: Cádiz Deleito, Maria Virginia / Galià Clua, Marina Teresa / Lligadas Puig, Gerard / Ronda Bargalló, Juan Carlos
Palabras clave: Vinylsulfide Undecylenic acid Sulfur-containing polyester Sulfur Renewable resource Polymer Polyesters Oxidation-responsive Nanomedicines Lipase-catalyzed synthesis Enzymatic polycondensation Drug delivery Derivatives Degradation Copolyesters Amphiphilic polymer
Resumen: © 2020 Elsevier Ltd The synthesis of oxidation-responsive biodegradable amphiphilic block copolymers by Candida Antarctica Lipase B (CALB)-catalyzed self-polycondensation of 11-((2-hydroxyethyl)-thio)undecanoic acid (TEHA) initiated by methoxy polyethyleneglycol (mPEG-OH) of different molecular weights has been described. SEC and mono and bidimensional NMR have been used to confirm the molecular weight and structure of the polymers and copolymers. DSC and TGA have been employed to characterize their thermal properties. The oxidation behaviour in front of H2O2 as well as the structure of the oxidized products has been established using NMR, FTIR and Raman spectroscopies. The different block copolymers could self-assemble to form nanosized micelles in aqueous solution with low critical micelle concentration (CMC), showing potential application as dual responsive systems in drug delivery. Micellar characteristics were investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). These micelles are prone to undergo a H2O2-triggered disassembly due to the oxidizable thioether groups in the hydrophobic core. Nile Red was used as model for hydrophobic drugs to test the oxidative triggered release of a copolymer, which showed progressive release in few hours upon the addition of H2O2.
Áreas temáticas: Química Polymers and plastics Polymer science Physics and astronomy (miscellaneous) Physics and astronomy (all) Organic chemistry Odontología Materials chemistry Materiais Interdisciplinar General physics and astronomy Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Ciências ambientais Ciência de alimentos Ciência da computação Biotecnología Astronomia / física Arquitetura, urbanismo e design
ISSN: 00143057
Direcció de correo del autor: gerard.lligadas@urv.cat virginia.cadiz@urv.cat juancarlos.ronda@urv.cat marina.galia@urv.cat
Identificador del autor: 0000-0002-8519-1840 0000-0003-2689-5407 0000-0002-0668-6600 0000-0002-4359-4510
Fecha de alta del registro: 2023-02-26
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0014305720308727
Referencia al articulo segun fuente origial: European Polymer Journal. 133 (109736): Article number 109736-
Referencia de l'ítem segons les normes APA: Valverde C; Lligadas G; Ronda JC; Galià M; Cádiz V (2020). Synthesis and characterization of castor oil-derived oxidation-responsive amphiphilic block copolymers: Poly(ethylene glycol)-b-poly(11-((2-hydroxyethyl)thio)undecanoate). European Polymer Journal, 133(109736), Article number 109736-. DOI: 10.1016/j.eurpolymj.2020.109736
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.eurpolymj.2020.109736
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV