Articles producció científica> Medicina i Cirurgia

Ceftolozane and tazobactam for the treatment of hospital acquired pneumonia

  • Datos identificativos

    Identificador: imarina:6858226
    Autores:
    Martin-Loeches I, Bisanti A, Diaz E, Rodriguez A
    Resumen:
    © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Patients admitted to hospitals are at risk of developing nosocomial infections. These types of infections typically occur in immune compromised patients. Furthermore, nosocomial infections are frequently caused by resistant organisms, including nonfermenting gram-negative bacilli such as Pseudomonas aeruginosa. Areas covered: P. aeruginosa is a hazardous pathogen. It can resist numerous antibiotics, due to several resistance mechanisms. It is associated with serious illnesses, particularly hospital acquired infections including ventilator associated pneumonia. In the past, only a limited number of anti-pseudomonal drugs were available. However, several therapeutic advancements have been made, in recent years, to target P. aeruginosa, including the development of the new cephalosporin: ceftolozane-tazobactam. Expert opinion: Ceftolozane-tazobactam is a combination of a novel semi-synthetic fifth generation cephalosporin with a well-established beta-lactamase inhibitor. From a structural perspective, ceftolozane-tazobactam has attested increased stability to AmpC β-lactamases. Additionally, ceftolozane-tazobactam is less affected by changes in efflux pumps and porin permeability due to an enhanced affinity to certain penicillin-binding proteins (PBPs). This enables the molecule to overcome the most common anti-drug resistant mechanisms of bacteria. According to previous clinical trials conducted, ceftolozane-tazobactam must be considered when treating patients with confirmed or suspected P. aeruginosa respiratory tract infections, either nosocomial pneumonia or ventilator-associated pneumonia.
  • Otros:

    Autor según el artículo: Martin-Loeches I, Bisanti A, Diaz E, Rodriguez A
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Rodríguez Oviedo, Alejandro Hugo
    Palabras clave: Vat Vap Urinary-tract-infections Sepsis Safety Resistance Renal-function Pseudomonas-aeruginosa Population pharmacokinetics Pneumonia Plus metronidazole P. aeruginosa P Multicenter Double-blind Cephalosporin Aeruginosa
    Resumen: © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Patients admitted to hospitals are at risk of developing nosocomial infections. These types of infections typically occur in immune compromised patients. Furthermore, nosocomial infections are frequently caused by resistant organisms, including nonfermenting gram-negative bacilli such as Pseudomonas aeruginosa. Areas covered: P. aeruginosa is a hazardous pathogen. It can resist numerous antibiotics, due to several resistance mechanisms. It is associated with serious illnesses, particularly hospital acquired infections including ventilator associated pneumonia. In the past, only a limited number of anti-pseudomonal drugs were available. However, several therapeutic advancements have been made, in recent years, to target P. aeruginosa, including the development of the new cephalosporin: ceftolozane-tazobactam. Expert opinion: Ceftolozane-tazobactam is a combination of a novel semi-synthetic fifth generation cephalosporin with a well-established beta-lactamase inhibitor. From a structural perspective, ceftolozane-tazobactam has attested increased stability to AmpC β-lactamases. Additionally, ceftolozane-tazobactam is less affected by changes in efflux pumps and porin permeability due to an enhanced affinity to certain penicillin-binding proteins (PBPs). This enables the molecule to overcome the most common anti-drug resistant mechanisms of bacteria. According to previous clinical trials conducted, ceftolozane-tazobactam must be considered when treating patients with confirmed or suspected P. aeruginosa respiratory tract infections, either nosocomial pneumonia or ventilator-associated pneumonia.
    Áreas temáticas: Virology Saúde coletiva Química Pharmacology & pharmacy Microbiology (medical) Microbiology Medicina ii Medicina i Infectious diseases Farmacia Engenharias iv Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14787210
    Direcció de correo del autor: alejandrohugo.rodriguez@urv.cat
    Identificador del autor: 0000-0001-8828-5984
    Fecha de alta del registro: 2023-09-02
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.tandfonline.com/doi/full/10.1080/14787210.2020.1794816?needAccess=true
    Referencia al articulo segun fuente origial: Expert Review Of Anti-Infective Therapy. 18 (12): 1-9
    Referencia de l'ítem segons les normes APA: Martin-Loeches I, Bisanti A, Diaz E, Rodriguez A (2020). Ceftolozane and tazobactam for the treatment of hospital acquired pneumonia. Expert Review Of Anti-Infective Therapy, 18(12), 1-9. DOI: 10.1080/14787210.2020.1794816
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1080/14787210.2020.1794816
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Microbiology,Microbiology (Medical),Pharmacology & Pharmacy,Virology
    Vat
    Vap
    Urinary-tract-infections
    Sepsis
    Safety
    Resistance
    Renal-function
    Pseudomonas-aeruginosa
    Population pharmacokinetics
    Pneumonia
    Plus metronidazole
    P. aeruginosa
    P
    Multicenter
    Double-blind
    Cephalosporin
    Aeruginosa
    Virology
    Saúde coletiva
    Química
    Pharmacology & pharmacy
    Microbiology (medical)
    Microbiology
    Medicina ii
    Medicina i
    Infectious diseases
    Farmacia
    Engenharias iv
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
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