Autor según el artículo: Martin-Loeches I, Bisanti A, Diaz E, Rodriguez A
Departamento: Medicina i Cirurgia
Autor/es de la URV: Rodríguez Oviedo, Alejandro Hugo
Palabras clave: Vat Vap Urinary-tract-infections Sepsis Safety Resistance Renal-function Pseudomonas-aeruginosa Population pharmacokinetics Pneumonia Plus metronidazole P. aeruginosa P Multicenter Double-blind Cephalosporin Aeruginosa
Resumen: © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Patients admitted to hospitals are at risk of developing nosocomial infections. These types of infections typically occur in immune compromised patients. Furthermore, nosocomial infections are frequently caused by resistant organisms, including nonfermenting gram-negative bacilli such as Pseudomonas aeruginosa. Areas covered: P. aeruginosa is a hazardous pathogen. It can resist numerous antibiotics, due to several resistance mechanisms. It is associated with serious illnesses, particularly hospital acquired infections including ventilator associated pneumonia. In the past, only a limited number of anti-pseudomonal drugs were available. However, several therapeutic advancements have been made, in recent years, to target P. aeruginosa, including the development of the new cephalosporin: ceftolozane-tazobactam. Expert opinion: Ceftolozane-tazobactam is a combination of a novel semi-synthetic fifth generation cephalosporin with a well-established beta-lactamase inhibitor. From a structural perspective, ceftolozane-tazobactam has attested increased stability to AmpC β-lactamases. Additionally, ceftolozane-tazobactam is less affected by changes in efflux pumps and porin permeability due to an enhanced affinity to certain penicillin-binding proteins (PBPs). This enables the molecule to overcome the most common anti-drug resistant mechanisms of bacteria. According to previous clinical trials conducted, ceftolozane-tazobactam must be considered when treating patients with confirmed or suspected P. aeruginosa respiratory tract infections, either nosocomial pneumonia or ventilator-associated pneumonia.
Áreas temáticas: Virology Saúde coletiva Química Pharmacology & pharmacy Microbiology (medical) Microbiology Medicina ii Medicina i Infectious diseases Farmacia Engenharias iv Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14787210
Direcció de correo del autor: alejandrohugo.rodriguez@urv.cat
Identificador del autor: 0000-0001-8828-5984
Fecha de alta del registro: 2023-09-02
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.tandfonline.com/doi/full/10.1080/14787210.2020.1794816?needAccess=true
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Expert Review Of Anti-Infective Therapy. 18 (12): 1-9
Referencia de l'ítem segons les normes APA: Martin-Loeches I, Bisanti A, Diaz E, Rodriguez A (2020). Ceftolozane and tazobactam for the treatment of hospital acquired pneumonia. Expert Review Of Anti-Infective Therapy, 18(12), 1-9. DOI: 10.1080/14787210.2020.1794816
DOI del artículo: 10.1080/14787210.2020.1794816
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV