Autor según el artículo: Ibanez, Raquel; Roura, Esther; Monfil, Laura; Alejandro Rodriguez, Luis; Sarda, Montserrat; Crespo, Nayade; Pascual, Amparo; Marti, Clara; Fibla, Montserrat; Gutierrez, Cristina; Lloveras, Belen; Oliveres, Gloria; Torrent, Anna; Catala, Isabel; Xavier Bosch, Francesc; Bruni, Laia; de Sanjose, Silvia
Departamento: Medicina i Cirurgia
Autor/es de la URV: Fibla Simó, Montserrat / GUTIÉRREZ FORNÉS, CRISTINA
Palabras clave: Uterine cervical neoplasms Time factors Risk Randomized controlled-trial Papillomaviridae Nonparticipation Middle aged Mass screening Humans Human-papillomavirus Guidelines Follow-up studies Female England Early detection of cancer Design Cytology Cohort studies Aged
Resumen: To evaluate the 9-year incidence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and cumulative adherence to perform a next test in a cohort of women aged 40+ years with no cervical screening cytology within a window of 5 years (underscreened women), after baseline cervical cytology and HPV tests.In Catalonia, Spain, co-testing with cytology and HPV test has been recommended in the Public Health system since 2006 for underscreened women. In 2007, 1,594 women with underscreened criteria were identified and followed through medical records form Pathological Department. 9-year cumulative incidence of histologically confirmed CIN2+ and cumulative adherence to perform a next test were estimated using Kaplan-Meier statistics.Follow-up was available for 1,009 women (63.3%) resulting in 23 women with. CIN2+ (2.3%). Of them, 4 women (17%) had both tests negative at baseline (3CIN2 and 1CIN3) with cumulative incidence of CIN2+ of 0.4% (95% CI: 0.1-1.4) at 5-years and 1.3% (95% CI: 0.4-3.7) at 9-years. During the first year, the prevalence among women with both tests positive was 27.0% (95% CI: 13.0-50.6) for CIN2+. Lost to follow-up was higher among women with both tests negative compared to those with both positive tests (38.7% vs 4.2%, p-value <0.001). 40.5% of the women HPV-/cyto- had a re-screening test during the 4 years following the baseline, increasing until 53.5% during the 6 years of follow-up.HPV detection shows a high longitudinal predictive value at 9-year to identify women at risk to develop CIN2+. The data validate a safe extension of the 3-year screening intervals (current screening interval) to 5-year intervals in underscreened women that had negative HPV result at baseline. It is necessary to establish mechanisms to ensure screening participation and adequate follow-up for these women.
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Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: montserrat.fibla@urv.cat
Identificador del autor: 0000-0001-6278-9324
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237988
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Plos One. 15 (8): e0237988-e0237988
Referencia de l'ítem segons les normes APA: Ibanez, Raquel; Roura, Esther; Monfil, Laura; Alejandro Rodriguez, Luis; Sarda, Montserrat; Crespo, Nayade; Pascual, Amparo; Marti, Clara; Fibla, Mont (2020). Long-term protection of HPV test in women at risk of cervical cancer. Plos One, 15(8), e0237988-e0237988. DOI: 10.1371/journal.pone.0237988
DOI del artículo: 10.1371/journal.pone.0237988
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV