Repositori URV

Autor según el artículo: Antequera-González, B; Martínez-Micaelo, N; Alegret, JM

Departamento: Medicina i Cirurgia

Autor/es de la URV: Alegret Colomé, Josep Maria / Antequera González, Borja / Martínez Micaelo, Nieves Beatriz

Palabras clave: Wall shear-stress Therapeutic target Progenitor cells Phosphorylation Nitric-oxide synthase Mesenchymal transition Magnetic-resonance Hemodynamics Flow patterns Endothelial dysfunction Endothelial cells Disease Cvd Colony-forming cells Biomarkers Biomarker Bicuspid aortic valve Activation

Resumen: © Copyright © 2020 Antequera-González, Martínez-Micaelo and Alegret. Bicuspid aortic valve (BAV), the most frequent congenital heart malformation, is characterized by the presence of a two-leaflet aortic valve instead of a three-leaflet one. BAV disease progression is associated with valvular dysfunction (in the form of stenosis or regurgitation) and aortopathy, which can lead to aneurysm and aortic dissection. This morphological abnormality modifies valve dynamics and promotes eccentric blood flow, which gives rise to alterations of the flow pattern and wall shear stress (WSS) of the ascending aorta. Recently, evidence of endothelial dysfunction (ED) in BAV disease has emerged. Different studies have addressed a reduced endothelial functionality by analyzing various molecular biomarkers and cellular parameters in BAV patients. Some authors have found impaired functionality of circulating endothelial progenitors in these patients, associating it with valvular dysfunction and aortic dilation. Others focused on systemic endothelial function by measuring artery flow-mediated dilation (FMD), showing a reduced FMD in BAV individuals. Novel biomarkers like increased endothelial microparticles (EMP), which are related to ED, have also been discovered in BAV patients. Finally, latest studies indicate that in BAV, endothelial-to-mesenchymal transition (EndoMT) may also be de-regulated, which could be caused by genetic, hemodynamic alterations, or both. Different hypothesis about the pathology of ED in BAV are nowadays being debated. Some authors blamed this impaired functionality just on genetic abnormalities, which could lead to a pathological aorta. Nevertheless, thanks to the development of new and high-resolution imaging techniques like 4D flow MRI, hemodynamics has gained great attention. Based on latest studies, alterations in blood flow seem to cause proper modification of the endothelial cells (ECs) function and morphology. It also seems to be associated with aortic dilation and decreased vasodilators expression, like nitric oxide (NO). Although nowadays ED in BAV has been reported by many, it is not clear which its main cause may be. Comprehending the pathways that promote ED and its relevance in BAV could help further understand and maybe prevent the serious consequences of this disease. This review will discuss the ED present in BAV, focusing on the latest evidence, biomarkers for ED and potential therapeutic targets (Figure 1).

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Physiology (medical) Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: neus.martinez@urv.cat josepmaria.alegret@urv.cat borja.antequera@estudiants.urv.cat

Identificador del autor: 0000-0002-6117-5512

Fecha de alta del registro: 2024-03-19

Volumen de revista: 11

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fphys.2020.01015/full

Referencia al articulo segun fuente origial: Frontiers In Physiology. 11 (1015): 1015-

Referencia de l'ítem segons les normes APA: Antequera-González, B; Martínez-Micaelo, N; Alegret, JM (2020). Bicuspid Aortic Valve and Endothelial Dysfunction: Current Evidence and Potential Therapeutic Targets. Frontiers In Physiology, 11(1015), 1015-. DOI: 10.3389/fphys.2020.01015

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI del artículo: 10.3389/fphys.2020.01015

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications